Description : Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p [Source:SGD;Acc:S000001762]
Gene families : OG_03_0001136 (OF) Phylogenetic Tree(s): OG0001136_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | HRR: YKR054C | |
| Cluster | HCCA: Cluster_12 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| AFR96214 | No alias | dynein heavy chain 1, cytosolic;Dynein heavy chain... | 0.17 | OF | |
| AOA68102 | No alias | Dynein heavy chain, domain-1 | 0.12 | OF | |
| CAG80308 | No alias | P-loop containing dynein motor region | 0.08 | OF | |
| CAK48678 | No alias | Dynein heavy chain AAA lid domain | 0.07 | OF | |
| CBF90163 | No alias | nudA description | 0.12 | OF | |
| EAL91432 | No alias | dynein heavy chain | 0.28 | OF | |
| EAU92970 | No alias | dynein | 0.15 | OF | |
| EDN92623 | No alias | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | 0.18 | OF | |
| EFI28556 | No alias | cytoplasmic dynein heavy chain 1 | 0.04 | OF | |
| EGR51787 | No alias | Dynein heavy chain region D6 P-loop domain | 0.02 | OF | |
| EJF58422 | No alias | Dynein heavy chain AAA lid domain | 0.09 | OF | |
| EJF58846 | No alias | Dynein heavy chain, N-terminal region 1 | 0.04 | OF | |
| ESA43035 | No alias | Dynein heavy chain, coiled coil stalk | 0.08 | OF | |
| ESA43036 | No alias | Dynein heavy chain, coiled coil stalk | 0.08 | OF | |
| ESU16215 | No alias | dynein heavy chain | 0.06 | OF | |
| KHC79064 | No alias | dynein heavy chain 1, cytosolic;Microtubule-binding... | 0.33 | OF | |
| MGG_11205T0 | No alias | Dynein heavy chain [Source:UniProtKB/TrEMBL;Acc:G4MSJ0] | 0.06 | OF | |
| SPAC1093.06c.1 | No alias | minus-end directed microtubule motor, dynein heavy chain... | 0.14 | OF |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0003777 | microtubule motor activity | IEA | Interproscan |
| MF | GO:0005524 | ATP binding | IEA | Interproscan |
| BP | GO:0007018 | microtubule-based movement | IEA | Interproscan |
| CC | GO:0030286 | dynein complex | IEA | Interproscan |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No Predicted GO terms available for this sequence |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR024743 | Dynein_HC_stalk | 3018 | 3346 |
| IPR041589 | DNAH3_AAA_lid_1 | 2607 | 2681 |
| IPR013594 | Dynein_heavy_dom-1 | 220 | 762 |
| IPR013602 | Dynein_heavy_dom-2 | 1222 | 1626 |
| IPR035699 | AAA_6 | 1758 | 2081 |
| IPR035706 | AAA_9 | 3378 | 3597 |
| IPR004273 | Dynein_heavy_D6_P-loop | 3791 | 3899 |
| IPR024317 | Dynein_heavy_chain_D4_dom | 2731 | 2937 |
| IPR041658 | AAA_lid_11 | 3928 | 4017 |
| No external refs found! |