Description : Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation [Source:SGD;Acc:S000003892]
Gene families : OG_03_0001308 (OF) Phylogenetic Tree(s): OG0001308_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | HRR: YJR131W | |
| Cluster | HCCA: Cluster_39 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| AOA68147 | No alias | Glycoside hydrolase family 47 | 0.02 | OF | |
| CAK43347 | No alias | Glycosyl hydrolase family 47 | 0.01 | OF | |
| EAA35037 | No alias | Glycoside hydrolase family 47 | 0.01 | OF | |
| EDO02037 | No alias | Glycoside hydrolase family 47 | 0.01 | OF | |
| KHC83150 | No alias | mannosyl-oligosaccharide 1,2-alpha-mannosidase;Glycosyl... | 0.02 | OF |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | IEA | Interproscan |
| MF | GO:0005509 | calcium ion binding | IEA | Interproscan |
| CC | GO:0016020 | membrane | IEA | Interproscan |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No Predicted GO terms available for this sequence |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR001382 | Glyco_hydro_47 | 45 | 532 |
| No external refs found! |