Description : Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress; previously thought to be a subunit of poly(A) ribonuclease [Source:SGD;Acc:S000001445]

Gene families : OG_03_0002107 (OF) Phylogenetic Tree(s): OG0002107_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YIR006C
Cluster HCCA: Cluster_56

Target Alias Description ECC score Gene Family Method Actions
AFR96434 No alias multidomain RhoGEF;Pleckstrin homology domain;WH2... 0.04 OF
AOA68617 No alias Domain of unknown function DUF1720 0.1 OF
CAG81042 No alias EH domain 0.07 OF
CAK46430 No alias Domain of unknown function (DUF1720) 0.05 OF
CBF74351 No alias Actin cytoskeleton-regulatory complex protein pan1 0.09 OF
EAA33504 No alias EH domain 0.06 OF
EAL87083 No alias actin cortical patch assembly protein Pan1, putative 0.12 OF
EAU81913 No alias Dbl homology (DH) domainSH3 domainSH3 domainEH... 0.06 OF
EDO03506 No alias EH domain 0.04 OF
EGR52784 No alias WH2 domain 0.09 OF
EJF56295 No alias Variant SH3 domain 0.03 OF
ESU13109 No alias EH domain 0.08 OF
KHC81398 No alias actin cytoskeleton-regulatory complex protein... 0.11 OF
SPAC25G10.09c.1 No alias actin cortical patch component, with EF hand and WH2... 0.07 OF

Type GO Term Name Evidence Source
MF GO:0005515 protein binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR013182 DUF1720 385 453
IPR013182 DUF1720 468 525
IPR013182 DUF1720 422 482
IPR000261 EH_dom 269 347
IPR000261 EH_dom 595 690
No external refs found!