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  5. YHR204W

YHR204W


Description : Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant [Source:SGD;Acc:S000001247]


Gene families : OG_03_0001926 (OF) Phylogenetic Tree(s): OG0001926_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood HRR: YHR204W
Cluster HCCA: Cluster_39

Target Alias Description ECC score Gene Family Method Actions
AFR98181 No alias carbohydrate binding protein;Glycosyl hydrolase family 47 0.02 OF
CAK40963 No alias Glycosyl hydrolase family 47 0.02 OF
EAA34492 No alias Glycoside hydrolase family 47 0.03 OF
EAL84665 No alias ER glycosyl hydrolase (Edem), putative 0.04 OF
EAU84717 No alias ER degradation-enhancing alpha-mannosidase-like 1 0.02 OF
EDO03161 No alias Glycoside hydrolase family 47 0.02 OF

Type GO Term Name Evidence Source
MF GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA Interproscan
MF GO:0005509 calcium ion binding IEA Interproscan
CC GO:0016020 membrane IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR001382 Glyco_hydro_47 43 501
No external refs found!