Description : Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p [Source:SGD;Acc:S000001078]

Gene families : OG_03_0000986 (OF) Phylogenetic Tree(s): OG0000986_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YHR036W
Cluster HCCA: Cluster_18

Target Alias Description ECC score Gene Family Method Actions
EJF58786 No alias Di-sulfide bridge nucleocytoplasmic transport domain 0.02 OF

Type GO Term Name Evidence Source
CC GO:0031965 nuclear membrane IEA Interproscan
BP GO:0055088 lipid homeostasis IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR018767 Brl1/Brr6_dom 296 427
No external refs found!