Description : Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p [Source:SGD;Acc:S000001078]
Gene families : OG_03_0000986 (OF) Phylogenetic Tree(s): OG0000986_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YHR036W | |
Cluster | HCCA: Cluster_18 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
EJF58786 | No alias | Di-sulfide bridge nucleocytoplasmic transport domain | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
CC | GO:0031965 | nuclear membrane | IEA | Interproscan |
BP | GO:0055088 | lipid homeostasis | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR018767 | Brl1/Brr6_dom | 296 | 427 |
No external refs found! |