Description : Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368]

Gene families : OG_03_0000786 (OF) Phylogenetic Tree(s): OG0000786_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YGR136W
Cluster HCCA: Cluster_46

Target Alias Description ECC score Gene Family Method Actions
EAA36600 No alias SH3 domain 0.04 OF
EDO02833 No alias SH3 domain 0.03 OF
ESU14437 No alias SH3 domain 0.03 OF
MGG_02835T0 No alias Putative uncharacterized protein... 0.04 OF

Type GO Term Name Evidence Source
MF GO:0005515 protein binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001452 SH3_domain 60 104
No external refs found!