Description : High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant [Source:SGD;Acc:S000003135]

Gene families : OG_03_0001687 (OF) Phylogenetic Tree(s): OG0001687_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YGL167C
Cluster HCCA: Cluster_13

Target Alias Description ECC score Gene Family Method Actions
AFR94400 No alias Ca2-transporting ATPase;Cation transporter/ATPase,... 0.03 OF
AOA65811 No alias Cation-transporting P-type ATPase, C-terminal 0.03 OF
CAK48875 No alias secretory pathway Ca2+-ATPase pmrA-Aspergillus niger 0.03 OF
CBF79432 No alias High affinity Ca2+/Mn2+ P-type ATPase 0.02 OF
EAA34982 No alias E1-E2 ATPase 0.03 OF
EAL87677 No alias calcium/mangenease P-type ATPase, putative 0.03 OF
EJF60700 No alias haloacid dehalogenase-like hydrolase 0.03 OF
ESU05697 No alias calcium-transporting ATPase 1 0.04 OF
KHC71728 No alias calcium-transporting P-type ATPase, PMR1-type;"Cation... 0.05 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR004014 ATPase_P-typ_cation-transptr_N 39 108
IPR006068 ATPase_P-typ_cation-transptr_C 762 934
No external refs found!