Description : S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 [Source:SGD;Acc:S000000120]
Gene families : OG_03_0001716 (OF) Phylogenetic Tree(s): OG0001716_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YBL024W | |
Cluster | HCCA: Cluster_16 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR95255 | No alias | multisite-specific... | 0.28 | OF | |
AOA70140 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.18 | OF | |
CAG79223 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.37 | OF | |
CAK44117 | No alias | 16S rRNA methyltransferase RsmB/F | 0.09 | OF | |
CBF88845 | No alias | methyltransferase | 0.2 | OF | |
EAA32836 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.19 | OF | |
EAL90750 | No alias | methyltransferase (Ncl1), putative | 0.26 | OF | |
EAU81513 | No alias | tRNA (cytosine-5-)-methyltransferase | 0.15 | OF | |
EDO00148 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.07 | OF | |
EED54457 | No alias | methyltransferase (Ncl1), putative | 0.04 | OF | |
EGR51707 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.06 | OF | |
EJF61835 | No alias | 16S rRNA methyltransferase RsmB/F | 0.05 | OF | |
ESU16367 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.19 | OF | |
KHC71376 | No alias | multisite-specific tRNA... | 0.36 | OF | |
MGG_13217T0 | No alias | tRNA (Cytosine-5-)-methyltransferase NCL1... | 0.18 | OF | |
POV94461 | No alias | SAM-dependent methyltransferase RsmB/NOP2-type | 0.06 | OF | |
SPAC17D4.04.1 | No alias | tRNA (cytosine-5-)-methyltransferase (predicted)... | 0.04 | OF | |
SPAC23C4.17.1 | No alias | tRNA (cytosine-5-)-methyltransferase (predicted)... | 0.2 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0008168 | methyltransferase activity | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR001678 | MeTrfase_RsmB/NOP2 | 159 | 408 |
No external refs found! |