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  5. YDR135C

YDR135C


Description : Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]


Gene families : OG_03_0000021 (OF) Phylogenetic Tree(s): OG0000021_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YDR135C
Cluster HCCA: Cluster_23

Target Alias Description ECC score Gene Family Method Actions
AFR93715 No alias metal resistance protein ycf1;ABC transporter... 0.03 OF
AFR97780 No alias ATP-binding cassette transporter;ABC transporter;ABC... 0.02 OF
CAG78123 No alias ABC transporter type 1, transmembrane domain 0.02 OF
CAG79528 No alias ABC transporter-like 0.03 OF
CAK46566 No alias ABC transporter transmembrane region 0.03 OF
CAK47845 No alias ABC transporter transmembrane region 0.02 OF
EAL91783 No alias ABC bile acid transporter, putative 0.04 OF
EAL91801 No alias ABC metal ion transporter, putative 0.05 OF
EDO03581 No alias ABC transporter-like 0.02 OF
EGR53081 No alias ABC transporter type 1, transmembrane domain 0.03 OF
ESU13567 No alias ABC transporter type 1, transmembrane domain 0.03 OF
ESU17713 No alias ABC transporter type 1, transmembrane domain 0.02 OF
KHC70681 No alias hypothetical protein;ABC transporter;ABC transporter... 0.02 OF
KHC71917 No alias hypothetical protein;ABC transporter transmembrane region 0.03 OF
POW13468 No alias ABC transporter type 1, transmembrane domain;ABC... 0.02 OF
YHL035C No alias Vacuolar membrane protein; involved in multiple drug... 0.04 OF
YLL015W No alias ABC type transmembrane transporter of MRP/CFTR family;... 0.03 OF

Type GO Term Name Evidence Source
MF GO:0005524 ATP binding IEA Interproscan
CC GO:0016021 integral component of membrane IEA Interproscan
MF GO:0016887 ATPase activity IEA Interproscan
MF GO:0042626 ATPase-coupled transmembrane transporter activity IEA Interproscan
BP GO:0055085 transmembrane transport IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR003439 ABC_transporter-like 1289 1438
IPR003439 ABC_transporter-like 646 780
IPR011527 ABC1_TM_dom 287 578
IPR011527 ABC1_TM_dom 952 1222
No external refs found!