YDR050C

Description : Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant [Source:SGD;Acc:S000002457]

Gene families : OG_03_0003730 (OF) Phylogenetic Tree(s): OG0003730_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YDR050C
Cluster	HCCA: Cluster_8

Target	Alias	Description	ECC score	Gene Family Method
AFR95784	No alias	triose-phosphate isomerase;Triosephosphate isomerase	0.08	OF
AOA68545	No alias	Triosephosphate isomerase	0.18	OF
CAG77830	No alias	Triosephosphate isomerase	0.03	OF
CAK42053	No alias	triose-phosphate-isomerase tpiA from patent...	0.03	OF
EAA29827	No alias	Triosephosphate isomerase	0.03	OF
EAL91271	No alias	triosephosphate isomerase	0.05	OF
EAU86629	No alias	triosephosphate isomerase	0.02	OF
EGR48570	No alias	Triosephosphate isomerase	0.04	OF
ESU12830	No alias	triosephosphate isomerase	0.03	OF
KHC79281	No alias	triosephosphate isomerase;Triosephosphate isomerase	0.11	OF
MGG_08905T0	No alias	Triosephosphate isomerase [Source:UniProtKB/TrEMBL;Acc:G4MVL8]	0.04	OF
SPCC24B10.21.1	No alias	triosephosphate isomerase [Source:PomBase;Acc:SPCC24B10.21]	0.04	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004807	triose-phosphate isomerase activity	IEA	Interproscan
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016860	intramolecular oxidoreductase activity	None	Extended
MF	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR000652	Triosephosphate_isomerase	6	244

External Links

No external refs found!

YDR050C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation