GO:0003714: transcription corepressor activity (Molecular function)

"A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]

There are 26 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_44 Aspergillus niger 0.74 % 0.019415 0.046353
Cluster_50 Candida albicans 2.53 % 0.000151 0.021193
Sequences (26) (download table)

InterPro Domains

GO Terms

Family Terms