Description : DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature [Source:SGD;Acc:S000002323]

Gene families : OG_03_0003578 (OF) Phylogenetic Tree(s): OG0003578_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDL164C
Cluster HCCA: Cluster_59

Target Alias Description ECC score Gene Family Method Actions
AFR97008 No alias DNA ligase 1;ATP dependent DNA ligase C terminal... 0.07 OF
CAG77648 No alias DNA ligase, ATP-dependent, C-terminal 0.03 OF
EGR46615 No alias DNA ligase, ATP-dependent, central 0.06 OF
KHC80031 No alias DNA ligase I, ATP-dependent (dnl1);ATP dependent DNA... 0.02 OF
POW11383 No alias DNA ligase, ATP-dependent, N-terminal;DNA ligase,... 0.03 OF
SPAC20G8.01.1 No alias ATP-dependent DNA replication ligase Cdc17... 0.02 OF

Type GO Term Name Evidence Source
MF GO:0003677 DNA binding IEA Interproscan
MF GO:0003910 DNA ligase (ATP) activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006281 DNA repair IEA Interproscan
BP GO:0006310 DNA recombination IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR012309 DNA_ligase_ATP-dep_C 623 732
IPR012308 DNA_ligase_ATP-dep_N 147 323
IPR012310 DNA_ligase_ATP-dep_cent 393 598
No external refs found!