Description : Cytoplasmic DEAD-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacting with both decapping and deadenylase complexes; role in translational repression, mRNA decay, and possibly mRNA export; interacts and cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body (PB) assembly, while ATPase stimulation by Not1p promotes PB disassembly; forms cytoplasmic foci on replication stress [Source:SGD;Acc:S000002319]

Gene families : OG_03_0001798 (OF) Phylogenetic Tree(s): OG0001798_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDL160C
Cluster HCCA: Cluster_56

Target Alias Description ECC score Gene Family Method Actions
AOA66773 No alias Helicase, C-terminal 0.03 OF
CAK40919 No alias Helicase conserved C-terminal domain 0.06 OF
ESU17989 No alias ATP-dependent RNA helicase DHH1 0.02 OF
KHC83468 No alias ATP-dependent RNA helicase DHH1;DEAD/DEAH box... 0.05 OF

Type GO Term Name Evidence Source
MF GO:0003676 nucleic acid binding IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR011545 DEAD/DEAH_box_helicase_dom 71 235
IPR001650 Helicase_C 271 378
No external refs found!