Description : Cytoplasmic DEAD-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacting with both decapping and deadenylase complexes; role in translational repression, mRNA decay, and possibly mRNA export; interacts and cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body (PB) assembly, while ATPase stimulation by Not1p promotes PB disassembly; forms cytoplasmic foci on replication stress [Source:SGD;Acc:S000002319]
Gene families : OG_03_0001798 (OF) Phylogenetic Tree(s): OG0001798_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YDL160C | |
Cluster | HCCA: Cluster_56 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AOA66773 | No alias | Helicase, C-terminal | 0.03 | OF | |
CAK40919 | No alias | Helicase conserved C-terminal domain | 0.06 | OF | |
ESU17989 | No alias | ATP-dependent RNA helicase DHH1 | 0.02 | OF | |
KHC83468 | No alias | ATP-dependent RNA helicase DHH1;DEAD/DEAH box... | 0.05 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003676 | nucleic acid binding | IEA | Interproscan |
MF | GO:0005524 | ATP binding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |