YCL030C

Description : Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis [Source:SGD;Acc:S000000535]

Gene families : OG_03_0002552 (OF) Phylogenetic Tree(s): OG0002552_tree

Sequence : coding (download), protein (download)

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Type	Description	Actions
Neighborhood	HRR: YCL030C
Cluster	HCCA: Cluster_7

Target	Alias	Description	ECC score	Gene Family Method
AOA65562	No alias	Histidinol dehydrogenase	0.13	OF
CAG84041	No alias	Histidinol dehydrogenase	0.26	OF
CAK37308	No alias	Phosphoribosyl-ATP pyrophosphohydrolase	0.15	OF
CBF88763	No alias	hypothetical histidine biosynthesis trifunctional protein	0.1	OF
EAA34952	No alias	Phosphoribosyl-ATP pyrophosphohydrolase-like	0.14	OF
EAL90788	No alias	phosphoribosyl-AMP cyclohydrolase, putative	0.04	OF
EAU84848	No alias	HIS4	0.07	OF
EDN96063	No alias	Histidinol dehydrogenase	0.07	OF
EGR47197	No alias	Phosphoribosyl-AMP cyclohydrolase domain	0.2	OF
EJF61201	No alias	Histidinol dehydrogenase	0.06	OF
ESU06107	No alias	histidine biosynthesis trifunctional protein	0.19	OF
KHC77966	No alias	histidine biosynthesis trifunctional...	0.2	OF
MGG_01309T0	No alias	Histidine biosynthesis trifunctional protein...	0.15	OF
SPBC1711.13.1	No alias	histidinol dehydrogenase His2 (predicted)...	0.15	OF

Type	GO Term	Name	Evidence	Source
BP	GO:0000105	histidine biosynthetic process	IEA	Interproscan
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004399	histidinol dehydrogenase activity	IEA	Interproscan
MF	GO:0004635	phosphoribosyl-AMP cyclohydrolase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006547	histidine metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008652	cellular amino acid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009072	aromatic amino acid family metabolic process	None	Extended
BP	GO:0009073	aromatic amino acid family biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	None	Extended
MF	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
MF	GO:0019238	cyclohydrolase activity	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	IEA	Interproscan
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
MF	GO:0051287	NAD binding	IEA	Interproscan
BP	GO:0052803	imidazole-containing compound metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	Interproscan
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901605	alpha-amino acid metabolic process	None	Extended
BP	GO:1901607	alpha-amino acid biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR021130	PRib-ATP_PPHydrolase-like	248	327
IPR002496	PRib_AMP_CycHydrolase_dom	166	238
IPR012131	Hstdl_DH	375	788

External Links

No external refs found!

YCL030C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation