1. Home
  2. Species
  3. Saccharomyces cerevisiae
  4. Sequence
  5. YPL153C

YPL153C


Description : DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]


Gene families : OG_03_0000062 (OF) Phylogenetic Tree(s): OG0000062_tree

Sequence : coding (download), protein (download)


Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YPL153C
Cluster HCCA: Cluster_37

Target Alias Description ECC score Gene Family Method Actions
AOA67549 No alias Forkhead-associated (FHA) domain 0.04 OF
AOA69093 No alias Protein kinase domain 0.04 OF
CAG78745 No alias Forkhead-associated (FHA) domain 0.05 OF
KHC75400 No alias serine/threonine-protein kinase Chk2;FHA domain;Protein... 0.06 OF
KHC78930 No alias Ser/Thr/Tyr protein kinase RAD53;FHA domain;Protein kinase domain 0.03 OF

Type GO Term Name Evidence Source
MF GO:0004672 protein kinase activity IEA Interproscan
MF GO:0005515 protein binding IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006468 protein phosphorylation IEA Interproscan
Toggle parental
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR000253 FHA_dom 66 133
IPR000253 FHA_dom 603 680
IPR000719 Prot_kinase_dom 201 466
No external refs found!