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YPL135W


Description : Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant [Source:SGD;Acc:S000006056]


Gene families : OG_03_0001901 (OF) Phylogenetic Tree(s): OG0001901_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YPL135W
Cluster HCCA: Cluster_38

Target Alias Description ECC score Gene Family Method Actions
AFR93539 No alias iron sulfur cluster assembly protein 2,... 0.02 OF
KHC71860 No alias iron sulfur cluster assembly protein 1,... 0.04 OF
MGG_01170T0 No alias Iron sulfur cluster assembly protein 2... 0.02 OF
POV94295 No alias NIF system FeS cluster assembly, NifU, N-terminal 0.02 OF
POW07703 No alias NIF system FeS cluster assembly, NifU, N-terminal 0.02 OF

Type GO Term Name Evidence Source
MF GO:0005506 iron ion binding IEA Interproscan
BP GO:0016226 iron-sulfur cluster assembly IEA Interproscan
MF GO:0051536 iron-sulfur cluster binding IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR002871 NIF_FeS_clus_asmbl_NifU_N 35 159
No external refs found!