YOR187W

Description : Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria [Source:SGD;Acc:S000005713]

Gene families : OG_03_0002489 (OF) Phylogenetic Tree(s): OG0002489_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YOR187W
Cluster	HCCA: Cluster_27

Target	Alias	Description	ECC score	Gene Family Method
AFR96484	No alias	translation elongation factor Tu;Elongation factor Tu...	0.06	OF
AOA69397	No alias	Translation elongation factor EFTu-like, domain 2	0.15	OF
CAG78638	No alias	Translation elongation factor EFTu-like, domain 2	0.09	OF
CAK45420	No alias	Elongation factor Tu C-terminal domain	0.2	OF
CBF88179	No alias	hypothetical protein similar to elongation factor EF-Tu	0.14	OF
EAA32277	No alias	Translation elongation factor EFTu-like, domain 2	0.23	OF
EAL90547	No alias	translation elongation factor EF-Tu, putative	0.2	OF
EAU93042	No alias	elongation factor Tu	0.07	OF
EDN90653	No alias	Translation elongation factor EFTu-like, domain 2	0.02	OF
EED82410	No alias	Translation elongation factor EFTu/EF1A, C-terminal	0.02	OF
EGR53068	No alias	Translation elongation factor EFTu-like, domain 2	0.13	OF
ESU13397	No alias	elongation factor Tu	0.19	OF
KHC82850	No alias	elongation factor Tu, mitochondrial;Elongation factor Tu...	0.15	OF
MGG_08162T0	No alias	Elongation factor Tu [Source:UniProtKB/TrEMBL;Acc:G4MYU6]	0.1	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0001882	nucleoside binding	None	Extended
MF	GO:0001883	purine nucleoside binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003924	GTPase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005525	GTP binding	IEA	Interproscan
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0019001	guanyl nucleotide binding	None	Extended
MF	GO:0032549	ribonucleoside binding	None	Extended
MF	GO:0032550	purine ribonucleoside binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032561	guanyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR004160	Transl_elong_EFTu/EF1A_C	337	435
IPR000795	TF_GTP-bd_dom	46	239
IPR004161	EFTu-like_2	263	332

External Links

No external refs found!

YOR187W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation