Description : Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication [Source:SGD;Acc:S000005612]
Gene families : OG_03_0000772 (OF) Phylogenetic Tree(s): OG0000772_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YOR086C | |
Cluster | HCCA: Cluster_34 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR98020 | No alias | transmembrane protein;C2 domain | 0.03 | OF | |
AGV14731 | No alias | transmembrane protein;C2 domain | 0.03 | OF | |
AOA66178 | No alias | C2 domain | 0.04 | OF | |
KHC83091 | No alias | hypothetical protein;C2 domain | 0.06 | OF | |
KHC83812 | No alias | hypothetical protein;C2 domain | 0.07 | OF | |
MGG_09947T0 | No alias | Tricalbin-1 [Source:UniProtKB/TrEMBL;Acc:G4MRL6] | 0.03 | OF | |
POW17974 | No alias | C2 domain | 0.03 | OF | |
SPAPYUK71.03c.1 | No alias | synaptotagmin family C2 domain protein, Syn1... | 0.03 | OF | |
YNL087W | No alias | ER protein involved in ER-plasma membrane tethering; one... | 0.04 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |