Description : Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress [Source:SGD;Acc:S000005381]
Gene families : OG_03_0003006 (OF) Phylogenetic Tree(s): OG0003006_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YOL021C | |
Cluster | HCCA: Cluster_63 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR95189 | No alias | exosome complex exonuclease DIS3/RRP44;S1... | 0.12 | OF | |
AOA68348 | No alias | Exosome complex exonuclease RRP44, S1 domain | 0.06 | OF | |
CAG79086 | No alias | PIN domain | 0.14 | OF | |
CAK96177 | No alias | Rrp44-like cold shock domain | 0.11 | OF | |
CBF75677 | No alias | putative TeaA receptor TeaR | 0.14 | OF | |
EAA34551 | No alias | Exosome complex exonuclease RRP44, S1 domain | 0.11 | OF | |
EAL89568 | No alias | exosome complex exonuclease exoribonuclease (Rrp44), putative | 0.16 | OF | |
EDN96634 | No alias | Dis3-like cold-shock domain 2 | 0.04 | OF | |
EFI27670 | No alias | mitotic control protein dis3 | 0.04 | OF | |
EGR47613 | No alias | Rrp44-like cold shock domain | 0.1 | OF | |
ESU06471 | No alias | mitotic control protein dis3 | 0.13 | OF | |
KHC83972 | No alias | VacB and RNase II family 3'-5'... | 0.25 | OF | |
MGG_00193T0 | No alias | Mitotic control protein dis3 [Source:UniProtKB/TrEMBL;Acc:G4NDV8] | 0.04 | OF | |
SPBC26H8.10.1 | No alias | 3'-5' exoribonuclease subunit Dis3... | 0.15 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003723 | RNA binding | IEA | Interproscan |
MF | GO:0004540 | ribonuclease activity | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |