YOL021C


Description : Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress [Source:SGD;Acc:S000005381]


Gene families : OG_03_0003006 (OF) Phylogenetic Tree(s): OG0003006_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YOL021C
Cluster HCCA: Cluster_63

Target Alias Description ECC score Gene Family Method Actions
AFR95189 No alias exosome complex exonuclease DIS3/RRP44;S1... 0.12 OF
AOA68348 No alias Exosome complex exonuclease RRP44, S1 domain 0.06 OF
CAG79086 No alias PIN domain 0.14 OF
CAK96177 No alias Rrp44-like cold shock domain 0.11 OF
CBF75677 No alias putative TeaA receptor TeaR 0.14 OF
EAA34551 No alias Exosome complex exonuclease RRP44, S1 domain 0.11 OF
EAL89568 No alias exosome complex exonuclease exoribonuclease (Rrp44), putative 0.16 OF
EDN96634 No alias Dis3-like cold-shock domain 2 0.04 OF
EFI27670 No alias mitotic control protein dis3 0.04 OF
EGR47613 No alias Rrp44-like cold shock domain 0.1 OF
ESU06471 No alias mitotic control protein dis3 0.13 OF
KHC83972 No alias VacB and RNase II family 3'-5'... 0.25 OF
MGG_00193T0 No alias Mitotic control protein dis3 [Source:UniProtKB/TrEMBL;Acc:G4NDV8] 0.04 OF
SPBC26H8.10.1 No alias 3'-5' exoribonuclease subunit Dis3... 0.15 OF

Type GO Term Name Evidence Source
MF GO:0003723 RNA binding IEA Interproscan
MF GO:0004540 ribonuclease activity IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR041505 Dis3_CSD2 422 489
IPR033771 Rrp44_CSD1 252 399
IPR002716 PIN_dom 88 206
IPR001900 RNase_II/R 531 860
IPR033770 RRP44_S1 913 997
No external refs found!