YNL088W


Description : Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant [Source:SGD;Acc:S000005032]


Gene families : OG_03_0001188 (OF) Phylogenetic Tree(s): OG0001188_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YNL088W
Cluster HCCA: Cluster_41

Target Alias Description ECC score Gene Family Method Actions
AOA68730 No alias DNA topoisomerase, type IIA, subunit B, domain 2 0.17 OF
CAG81413 No alias TOPRIM domain 0.15 OF
CAK96636 No alias DNA gyrase/topoisomerase IV, subunit A 0.13 OF
CBF81963 No alias DNA topoisomerase 2 0.12 OF
EAL89207 No alias DNA topoisomerase II 0.07 OF
EAU92936 No alias DNA topoisomerase II 0.04 OF
EDN97002 No alias TOPRIM domain 0.08 OF
EED45000 No alias DNA topoisomerase II 0.02 OF
EGR51999 No alias Histidine kinase/HSP90-like ATPase 0.05 OF
EJF58805 No alias DNA gyrase/topoisomerase IV, subunit A 0.05 OF
ESA42913 No alias C-terminal associated domain of TOPRIM 0.16 OF
ESU16429 No alias DNA topoisomerase 2 0.21 OF
KHC76731 No alias DNA topoisomerase 2;"DNA gyrase/topoisomerase IV,... 0.23 OF
MGG_06162T0 No alias DNA topoisomerase 2 [Source:UniProtKB/TrEMBL;Acc:G4MZZ7] 0.12 OF
POW17206 No alias C-terminal associated domain of TOPRIM;DNA... 0.05 OF
SPBC1A4.03c.1 No alias DNA topoisomerase II [Source:PomBase;Acc:SPBC1A4.03c] 0.09 OF

Type GO Term Name Evidence Source
MF GO:0003677 DNA binding IEA Interproscan
MF GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0006265 DNA topological change IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR006171 TOPRIM_domain 445 543
IPR003594 HATPase_C 58 204
IPR013506 Topo_IIA_bsu_dom2 247 373
IPR031660 TOPRIM_C 559 688
IPR002205 Topo_IIA_A/C 690 1160
No external refs found!