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  5. YNL061W

YNL061W


Description : rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer [Source:SGD;Acc:S000005005]


Gene families : OG_03_0003140 (OF) Phylogenetic Tree(s): OG0003140_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YNL061W
Cluster HCCA: Cluster_16

Target Alias Description ECC score Gene Family Method Actions
AFR93230 No alias ribosomal RNA methyltransferase Nop2;16S rRNA... 0.25 OF
AOA67419 No alias SAM-dependent methyltransferase RsmB/NOP2-type 0.24 OF
CAG82971 No alias SAM-dependent methyltransferase RsmB/NOP2-type 0.34 OF
CAK42767 No alias N-terminal domain of 16S rRNA methyltransferase RsmF 0.28 OF
CBF73828 No alias nucleolar RNA methyltransferase 0.25 OF
EAA36406 No alias SAM-dependent methyltransferase RsmB/NOP2-type 0.28 OF
EAL86128 No alias nucleolar RNA methyltransferase (Nop2), putative 0.33 OF
EAU88451 No alias tRNA (cytosine-5-)-methyltransferase NSUN2 0.06 OF
EDN97164 No alias SAM-dependent methyltransferase RsmB/NOP2-type 0.26 OF
EGR52534 No alias Ribosomal RNA small subunit methyltransferase F, N-terminal 0.18 OF
ESU12315 No alias nucleolar protein 2 0.27 OF
KHC71363 No alias ribosomal RNA methyltransferase Nop2;16S rRNA... 0.31 OF
MGG_01292T0 No alias Nucleolar protein NOP2 [Source:UniProtKB/TrEMBL;Acc:G4MY77] 0.27 OF
POW01721 No alias Ribosomal RNA small subunit methyltransferase F,... 0.07 OF
SPBP8B7.20c.1 No alias RNA methyltransferase Nop2 (predicted)... 0.24 OF

Type GO Term Name Evidence Source
MF GO:0008168 methyltransferase activity IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR001678 MeTrfase_RsmB/NOP2 338 547
IPR031341 Methyltr_RsmF_N 255 334
No external refs found!