YBR218C

Description : Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000422]

Gene families : OG_03_0000155 (OF) Phylogenetic Tree(s): OG0000155_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YBR218C
Cluster	HCCA: Cluster_7

Target	Alias	Description	ECC score	Gene Family Method
AFR96227	No alias	pyruvate carboxylase;Carbamoyl-phosphate synthase L...	0.05	OF
CBF77471	No alias	pyruvate carboxylase	0.02	OF
EAA36400	No alias	Biotin carboxylase, C-terminal	0.05	OF
EAL90016	No alias	pyruvate carboxylase, putative	0.19	OF
ESU13268	No alias	pyruvate carboxylase	0.04	OF
KHC76480	No alias	pyruvate carboxylase;Conserved carboxylase...	0.12	OF
KHC77660	No alias	pyruvate carboxylase;Conserved carboxylase...	0.12	OF
SPBC17G9.11c.1	No alias	pyruvate carboxylase Pyr1 [Source:PomBase;Acc:SPBC17G9.11c]	0.1	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
MF	GO:0008144	drug binding	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR005482	Biotin_COase_C	360	467
IPR003379	Carboxylase_cons_dom	852	1052
IPR000891	PYR_CT	560	828
IPR005479	CbamoylP_synth_lsu-like_ATP-bd	136	344
IPR005481	BC-like_N	21	131
IPR000089	Biotin_lipoyl	1102	1169

External Links

No external refs found!

YBR218C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation