Description : Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface [Source:SGD;Acc:S000004813]
Gene families : OG_03_0004445 (OF) Phylogenetic Tree(s): OG0004445_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YMR200W | |
Cluster | HCCA: Cluster_46 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AOA65822 | No alias | Protein Rot1 | 0.03 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
CC | GO:0005783 | endoplasmic reticulum | IEA | Interproscan |
BP | GO:0006458 | 'de novo' protein folding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR019623 | Rot1 | 31 | 253 |
No external refs found! |