Description : ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress [Source:SGD;Acc:S000004685]

Gene families : OG_03_0000143 (OF) Phylogenetic Tree(s): OG0000143_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YMR080C
Cluster HCCA: Cluster_54

Target Alias Description ECC score Gene Family Method Actions
AFR94410 No alias DNA helicase;AAA domain 0.02 OF
AOA68249 No alias RNA helicase UPF1, UPF2-interacting domain 0.05 OF
CAG81409 No alias RNA helicase UPF1, UPF2-interacting domain 0.03 OF
CAK45574 No alias RNA helicase (UPF2 interacting domain) 0.03 OF
EAA31997 No alias DNA2/NAM7 helicase, AAA domain 0.06 OF
EAL87207 No alias DNA helicase, putative 0.02 OF
EAL90638 No alias regulator of nonsense transcripts, putative 0.15 OF
EAU88694 No alias ATP dependent helicase 0.04 OF
EDN91568 No alias DNA2/NAM7 helicase-like, AAA domain 0.06 OF
ESU16575 No alias ATP-dependent helicase NAM7 0.11 OF
KHC70522 No alias hypothetical protein;AAA domain 0.08 OF
KHC74964 No alias hypothetical protein;AAA domain;RNA helicase (UPF2... 0.05 OF
MGG_00976T0 No alias Regulator-nonsense transcripts 1... 0.11 OF
POW07607 No alias DNA2/NAM7 helicase, AAA domain;DNA2/NAM7 helicase-like,... 0.03 OF
SPAC16C9.06c.1 No alias ATP-dependent RNA helicase Upf1 [Source:PomBase;Acc:SPAC16C9.06c] 0.08 OF

Type GO Term Name Evidence Source
BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA Interproscan
MF GO:0003677 DNA binding IEA Interproscan
MF GO:0004386 helicase activity IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
CC GO:0005737 cytoplasm IEA Interproscan
MF GO:0008270 zinc ion binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR041679 DNA2/NAM7-like_AAA 616 812
IPR040812 DUF5599 260 352
IPR041677 DNA2/NAM7_AAA_11 408 505
IPR041677 DNA2/NAM7_AAA_11 519 608
IPR018999 RNA-helicase_UPF1_UPF2-interct 61 208
No external refs found!