Description : HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]

Gene families : OG_03_0001052 (OF) Phylogenetic Tree(s): OG0001052_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YML075C
Cluster HCCA: Cluster_17

Target Alias Description ECC score Gene Family Method Actions
CAK38517 No alias Hydroxymethylglutaryl-coenzyme A reductase 0.02 OF
CBF75320 No alias hypothetical protein similar to HMG-CoA reductase 0.07 OF
EAU81445 No alias hydroxymethylglutaryl-CoA reductase 0.05 OF
EDO03537 No alias Hydroxymethylglutaryl-CoA reductase, class I/II 0.03 OF
EGR52932 No alias Hydroxymethylglutaryl-CoA reductase, class I/II 0.04 OF
ESU15734 No alias 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.16 OF
KHC83155 No alias hydroxymethylglutaryl-CoA reductase (NADPH);N-terminal... 0.04 OF
POW10287 No alias Hydroxymethylglutaryl-CoA reductase, class I/II 0.03 OF
SPCC162.09c.1 No alias 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1... 0.03 OF

Type GO Term Name Evidence Source
MF GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA Interproscan
BP GO:0015936 coenzyme A metabolic process IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR025583 HMG-CoA_N_dom 10 160
IPR000731 SSD 216 360
IPR002202 HMG_CoA_Rdtase 646 1025
No external refs found!