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  5. YLR450W

YLR450W


Description : HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant [Source:SGD;Acc:S000004442]


Gene families : OG_03_0001052 (OF) Phylogenetic Tree(s): OG0001052_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YLR450W
Cluster HCCA: Cluster_39

Target Alias Description ECC score Gene Family Method Actions
CAK38517 No alias Hydroxymethylglutaryl-coenzyme A reductase 0.02 OF
EDO03537 No alias Hydroxymethylglutaryl-CoA reductase, class I/II 0.05 OF
KHC83155 No alias hydroxymethylglutaryl-CoA reductase (NADPH);N-terminal... 0.03 OF
SPCC162.09c.1 No alias 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1... 0.08 OF

Type GO Term Name Evidence Source
MF GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA Interproscan
BP GO:0015936 coenzyme A metabolic process IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR025583 HMG-CoA_N_dom 10 159
IPR000731 SSD 213 360
IPR002202 HMG_CoA_Rdtase 644 1021
No external refs found!