Description : Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain [Source:SGD;Acc:S000004301]
Gene families : OG_03_0000194 (OF) Phylogenetic Tree(s): OG0000194_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YLR310C | |
Cluster | HCCA: Cluster_56 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AGV14832 | No alias | cell division control protein 25, variant;RasGEF... | 0.02 | OF | |
AOA65644 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.05 | OF | |
CAG81343 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.05 | OF | |
CAK42617 | No alias | RasGEF domain | 0.07 | OF | |
CBF86239 | No alias | cell division control protein Cdc25, putative | 0.02 | OF | |
EAA27904 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.04 | OF | |
EAU85921 | No alias | Ras-like guanine nucleotide exchange factor,... | 0.02 | OF | |
EAU92277 | No alias | Ras-like guanine nucleotide exchange factor, N-terminalSH3 domain | 0.02 | OF | |
EDO00640 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.04 | OF | |
EED82271 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.05 | OF | |
EGR44340 | No alias | SH3 domain | 0.03 | OF | |
ESU11353 | No alias | Ras guanine-nucleotide exchange factors catalytic domain | 0.09 | OF | |
ESU17875 | No alias | Ras-like guanine nucleotide exchange factor, N-terminal | 0.02 | OF | |
KHC70543 | No alias | hypothetical protein;RasGEF N-terminal motif;RasGEF domain | 0.05 | OF | |
KHC78938 | No alias | hypothetical protein;RasGEF domain;SH3 domain;RasGEF... | 0.06 | OF | |
MGG_00371T0 | No alias | Cell division control protein 25... | 0.05 | OF | |
POW05769 | No alias | SH3 domain;Ras guanine-nucleotide exchange factors... | 0.01 | OF | |
SPBC336.03.1 | No alias | Ras1 guanyl-nucleotide exchange factor Efc25... | 0.04 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | Interproscan |
MF | GO:0005515 | protein binding | IEA | Interproscan |
BP | GO:0007264 | small GTPase mediated signal transduction | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |