Description : Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant [Source:SGD;Acc:S000004176]
Gene families : OG_03_0002302 (OF) Phylogenetic Tree(s): OG0002302_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | HRR: YLR186W | |
| Cluster | HCCA: Cluster_69 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| AFR97447 | No alias | nucleolar essential protein 1;EMG1/NEP1 methyltransferase | 0.12 | OF | |
| AOA66426 | No alias | Ribosomal biogenesis, methyltransferase, EMG1/NEP1 | 0.02 | OF | |
| CAG78997 | No alias | Ribosomal biogenesis, methyltransferase, EMG1/NEP1 | 0.06 | OF | |
| ESU16489 | No alias | nucleolar essential protein 1 | 0.03 | OF | |
| KHC83880 | No alias | ribosomal RNA small subunit methyltransferase... | 0.06 | OF | |
| SPAC18G6.07c.1 | No alias | rRNA (pseudouridine) methyltransferase Mra1... | 0.11 | OF |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0008168 | methyltransferase activity | IEA | Interproscan |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No Predicted GO terms available for this sequence |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR005304 | Rbsml_bgen_MeTrfase_EMG1/NEP1 | 43 | 246 |
| No external refs found! |