Description : DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, error-prone translesion synthesis; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells; human homolog HLTF can complement yeast null mutant [Source:SGD;Acc:S000004022]

Gene families : OG_03_0003227 (OF) Phylogenetic Tree(s): OG0003227_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YLR032W
Cluster HCCA: Cluster_59

Target Alias Description ECC score Gene Family Method Actions
CAG77851 No alias HIRAN domain 0.02 OF
CBF90313 No alias DNA repair protein rad5 0.03 OF
EAA29275 No alias SNF2-related, N-terminal domain 0.07 OF
EDO00739 No alias Zinc finger, C3HC4 RING-type 0.06 OF
EGR50103 No alias SNF2-related, N-terminal domain 0.1 OF
ESU08197 No alias DNA repair protein RAD5 0.05 OF
POW04855 No alias Zinc finger, C3HC4 type (RING finger);SNF2-related,... 0.03 OF

Type GO Term Name Evidence Source
MF GO:0003676 nucleic acid binding IEA Interproscan
MF GO:0005524 ATP binding IEA Interproscan
MF GO:0008270 zinc ion binding IEA Interproscan
MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001841 Znf_RING 913 961
IPR014905 HIRAN 176 283
IPR001650 Helicase_C 996 1115
IPR000330 SNF2_N 440 847
No external refs found!