YKL049C

Description : Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N-terminus regulates proteolysis for faithful chromosome segregation; yeast CSE4 can complement mutations in human homolog CENPA [Source:SGD;Acc:S000001532]

Gene families : OG_03_0050993 (OF) Phylogenetic Tree(s): No tree available for this family

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YKL049C
Cluster	HCCA: Cluster_11

Type	GO Term	Name	Evidence	Source
CC	GO:0000786	nucleosome	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
CC	GO:0032993	protein-DNA complex	None	Extended
CC	GO:0044815	DNA packaging complex	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR007125	Histone_H2A/H2B/H3	98	225

External Links

No external refs found!

YKL049C

Expression Profile

Co-expression Networks

Functional Annotation