YKL040C


Description : Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1) [Source:SGD;Acc:S000001523]


Gene families : OG_03_0001559 (OF) Phylogenetic Tree(s): OG0001559_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YKL040C
Cluster HCCA: Cluster_46

Target Alias Description ECC score Gene Family Method Actions
AFR96617 No alias NifU-like protein c;Scaffold protein Nfu/NifU N... 0.02 OF
AOA65814 No alias Scaffold protein Nfu/NifU, N-terminal 0.04 OF
EAA27966 No alias Scaffold protein Nfu/NifU, N-terminal 0.05 OF
EGR48073 No alias Scaffold protein Nfu/NifU, N-terminal 0.02 OF
EJF58562 No alias NifU-like domain 0.02 OF
ESU05861 No alias Scaffold protein Nfu/NifU, N-terminal 0.05 OF
KHC81136 No alias hypothetical protein;Scaffold protein Nfu/NifU N... 0.12 OF
POW08260 No alias NIF system FeS cluster assembly, NifU,... 0.02 OF

Type GO Term Name Evidence Source
MF GO:0005506 iron ion binding IEA Interproscan
BP GO:0016226 iron-sulfur cluster assembly IEA Interproscan
MF GO:0051536 iron-sulfur cluster binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001075 NIF_FeS_clus_asmbl_NifU_C 157 225
IPR014824 Nfu/NifU_N 24 115
No external refs found!