Description : Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1) [Source:SGD;Acc:S000001523]
Gene families : OG_03_0001559 (OF) Phylogenetic Tree(s): OG0001559_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YKL040C | |
Cluster | HCCA: Cluster_46 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
AFR96617 | No alias | NifU-like protein c;Scaffold protein Nfu/NifU N... | 0.02 | OF | |
AOA65814 | No alias | Scaffold protein Nfu/NifU, N-terminal | 0.04 | OF | |
EAA27966 | No alias | Scaffold protein Nfu/NifU, N-terminal | 0.05 | OF | |
EGR48073 | No alias | Scaffold protein Nfu/NifU, N-terminal | 0.02 | OF | |
EJF58562 | No alias | NifU-like domain | 0.02 | OF | |
ESU05861 | No alias | Scaffold protein Nfu/NifU, N-terminal | 0.05 | OF | |
KHC81136 | No alias | hypothetical protein;Scaffold protein Nfu/NifU N... | 0.12 | OF | |
POW08260 | No alias | NIF system FeS cluster assembly, NifU,... | 0.02 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0005506 | iron ion binding | IEA | Interproscan |
BP | GO:0016226 | iron-sulfur cluster assembly | IEA | Interproscan |
MF | GO:0051536 | iron-sulfur cluster binding | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
No external refs found! |