Description : Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP [Source:SGD;Acc:S000003666]
Gene families : OG_03_0002435 (OF) Phylogenetic Tree(s): OG0002435_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YJL130C | |
Cluster | HCCA: Cluster_7 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
CAG79327 | No alias | Carbamoyl-phosphate synthetase, large subunit... | 0.04 | OF | |
CBF89223 | No alias | Protein pyrABCN [Includes Glutamine-dependent... | 0.03 | OF | |
EAL88977 | No alias | bifunctional pyrimidine biosynthesis protein (PyrABCN), putative | 0.04 | OF | |
EDN92690 | No alias | Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding | 0.01 | OF | |
EGR51761 | No alias | Carbamoyl-phosphate synthetase, large subunit... | 0.04 | OF | |
KHC70557 | No alias | protein URA1;MGS-like domain;"Carbamoyl-phosphate... | 0.06 | OF | |
POW14164 | No alias | Glutamine amidotransferase;Carbamoyl-phosphate... | 0.02 | OF | |
SPAC22G7.06c.1 | No alias | carbamoyl-phosphate synthase (glutamine hydrolyzing),... | 0.06 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0005524 | ATP binding | IEA | Interproscan |
BP | GO:0006520 | cellular amino acid metabolic process | IEA | Interproscan |
MF | GO:0016597 | amino acid binding | IEA | Interproscan |
MF | GO:0016743 | carboxyl- or carbamoyltransferase activity | IEA | Interproscan |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR011607 | MGS-like_dom | 1375 | 1473 |
IPR002474 | CarbamoylP_synth_ssu_N | 23 | 160 |
IPR006132 | Asp/Orn_carbamoyltranf_P-bd | 1911 | 2052 |
IPR005480 | CarbamoylP_synth_lsu_oligo | 846 | 968 |
IPR006131 | Asp_carbamoyltransf_Asp/Orn-bd | 2059 | 2208 |
IPR017926 | GATASE | 231 | 406 |
IPR005479 | CbamoylP_synth_lsu-like_ATP-bd | 1095 | 1294 |
IPR005479 | CbamoylP_synth_lsu-like_ATP-bd | 557 | 760 |
No external refs found! |