Description : Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication [Source:SGD;Acc:S000001175]
Gene families : OG_03_0004018 (OF) Phylogenetic Tree(s): OG0004018_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | HRR: YHR133C | |
Cluster | HCCA: Cluster_55 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
SPCC306.05c.1 | No alias | INSIG domain protein [Source:PomBase;Acc:SPCC306.05c] | 0.03 | OF |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No Predicted GO terms available for this sequence |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR025929 | INSIG_fam | 105 | 259 |
No external refs found! |