YHR133C


Description : Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication [Source:SGD;Acc:S000001175]


Gene families : OG_03_0004018 (OF) Phylogenetic Tree(s): OG0004018_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YHR133C
Cluster HCCA: Cluster_55

Target Alias Description ECC score Gene Family Method Actions
SPCC306.05c.1 No alias INSIG domain protein [Source:PomBase;Acc:SPCC306.05c] 0.03 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR025929 INSIG_fam 105 259
No external refs found!