Description : Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation [Source:SGD;Acc:S000001049]

Gene families : OG_03_0000705 (OF) Phylogenetic Tree(s): OG0000705_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YHR007C
Cluster HCCA: Cluster_17

Target Alias Description ECC score Gene Family Method Actions
AFR92179 No alias cytochrome P450, family 51 (sterol... 0.21 OF
AOA68525 No alias Cytochrome P450 0.14 OF
CAG82748 No alias Cytochrome P450 0.04 OF
CAK40582 No alias Cytochrome P450 0.06 OF
CBF85786 No alias Cytochrome P450 sterol 14 alpha-demethylase 0.08 OF
EAA34813 No alias Cytochrome P450 0.08 OF
EAL87096 No alias 14-alpha sterol demethylase Cyp51B 0.06 OF
EAL90099 No alias 14-alpha sterol demethylase Cyp51A 0.07 OF
EAU85335 No alias lanosterol 14-alpha-demethylase 0.16 OF
EAU90091 No alias lanosterol 14-alpha-demethylase 0.06 OF
EGR51226 No alias Cytochrome P450 0.07 OF
ESU06265 No alias cytochrome P450 51 0.12 OF
ESU09049 No alias cytochrome P450 51 0.06 OF
KHC74980 No alias lanosterol 14-alpha demethylase;Cytochrome P450 0.18 OF
MGG_04432T0 No alias Cytochrome P450 51 [Source:UniProtKB/TrEMBL;Acc:G4MZG5] 0.02 OF
SPAC13A11.02c.1 No alias sterol 14-demethylase Erg11 (predicted)... 0.09 OF

Type GO Term Name Evidence Source
MF GO:0005506 iron ion binding IEA Interproscan
MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA Interproscan
MF GO:0020037 heme binding IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001128 Cyt_P450 57 520
No external refs found!