Description : Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000995]

Gene families : OG_03_0001890 (OF) Phylogenetic Tree(s): OG0001890_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YHL003C
Cluster HCCA: Cluster_55

Target Alias Description ECC score Gene Family Method Actions
CAK96890 No alias TLC domain 0.02 OF
CBF86909 No alias ceramide synthase LagA 0.03 OF
EAA27759 No alias TRAM/LAG1/CLN8 homology domain 0.06 OF
EAU84867 No alias longevity-assurance protein 1 0.04 OF
EDO00725 No alias TRAM/LAG1/CLN8 homology domain 0.02 OF
KHC71083 No alias acyl-CoA-dependent ceramide synthase;TRAM1-like... 0.06 OF

Type GO Term Name Evidence Source
CC GO:0016021 integral component of membrane IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR013599 TRAM1 110 167
IPR006634 TLC-dom 173 377
No external refs found!