YGR175C


Description : Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation [Source:SGD;Acc:S000003407]


Gene families : OG_03_0001768 (OF) Phylogenetic Tree(s): OG0001768_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YGR175C
Cluster HCCA: Cluster_17

Target Alias Description ECC score Gene Family Method Actions
AFR94648 No alias squalene monooxygenase;Squalene epoxidase 0.06 OF
AOA69363 No alias Squalene epoxidase 0.09 OF
CAG79587 No alias Squalene epoxidase 0.02 OF
CAK47816 No alias Squalene epoxidase 0.03 OF
CBF80034 No alias Squalene epoxidase 0.04 OF
EAA32570 No alias FAD dependent oxidoreductase 0.05 OF
EAL91820 No alias squalene monooxygenase Erg1 0.06 OF
EAU90718 No alias squalene epoxidase 0.12 OF
EDN98227 No alias FAD dependent oxidoreductase 0.03 OF
EJF62076 No alias Squalene epoxidase 0.07 OF
ESU12284 No alias FAD-binding domain 0.12 OF
KHC83608 No alias squalene monooxygenase;Squalene epoxidase 0.1 OF
SPBC713.12.1 No alias squalene monooxygenase Erg1 (predicted)... 0.09 OF

Type GO Term Name Evidence Source
MF GO:0004506 squalene monooxygenase activity IEA Interproscan
CC GO:0016021 integral component of membrane IEA Interproscan
MF GO:0050660 flavin adenine dinucleotide binding IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR013698 Squalene_epoxidase 201 473
No external refs found!