YGL245W

Description : Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003214]

Gene families : OG_03_0002326 (OF) Phylogenetic Tree(s): OG0002326_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YGL245W
Cluster	HCCA: Cluster_8

Target	Alias	Description	ECC score	Gene Family Method
AFR96299	No alias	glutamate-tRNA ligase;tRNA synthetases class I (E and...	0.14	OF
AOA65815	No alias	Glutamate--tRNA ligase, N-terminal domain	0.17	OF
CAG80111	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib,...	0.08	OF
CAK40405	No alias	tRNA synthetases class I (E and Q), catalytic domain	0.02	OF
CBF74148	No alias	glutamyl-tRNA synthetase	0.1	OF
EAA29596	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	0.1	OF
EAL85950	No alias	glutamyl-tRNA synthetase	0.21	OF
EAU88705	No alias	glutamate-tRNA ligase	0.12	OF
EDO01325	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	0.08	OF
EGR49599	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	0.1	OF
ESU08503	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	0.04	OF
KHC71756	No alias	glutamate-tRNA ligase;"tRNA synthetases class I (E and...	0.25	OF
MGG_05956T0	No alias	Glutamyl-tRNA synthetase [Source:UniProtKB/TrEMBL;Acc:G4N4B9]	0.09	OF
POW02019	No alias	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic...	0.08	OF
SPAC17A5.15c.1	No alias	cytoplasmic glutamate-tRNA ligase gus1 (predicted)...	0.18	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006399	tRNA metabolic process	None	Extended
BP	GO:0006418	tRNA aminoacylation for protein translation	IEA	Interproscan
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016070	RNA metabolic process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034660	ncRNA metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0043038	amino acid activation	None	Extended
BP	GO:0043039	tRNA aminoacylation	IEA	Interproscan
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:0140098	catalytic activity, acting on RNA	None	Extended
MF	GO:0140101	catalytic activity, acting on a tRNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR020058	Glu/Gln-tRNA-synth_Ib_cat-dom	201	506
IPR041103	GluRS_N	23	63
IPR020059	Glu/Gln-tRNA-synth_Ib_codon-bd	509	681

External Links

No external refs found!

YGL245W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation