Description : Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression [Source:SGD;Acc:S000003207]

Gene families : OG_03_0002893 (OF) Phylogenetic Tree(s): OG0002893_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YGL238W
Cluster HCCA: Cluster_63

Target Alias Description ECC score Gene Family Method Actions
AFR97904 No alias importin-alpha export receptor;CAS/CSE protein,... 0.07 OF
AOA68271 No alias Importin-beta, N-terminal domain 0.07 OF
CAG79236 No alias Importin-beta, N-terminal domain 0.08 OF
CAL00938 No alias Cse1 0.06 OF
CBF71053 No alias KapEPutative uncharacterized protein 0.07 OF
EAA31630 No alias Importin-beta, N-terminal domain 0.06 OF
EAL85638 No alias chromosome segregation protein Cse1, putative 0.1 OF
EAU80449 No alias importin alpha re-exporter 0.06 OF
EDN91166 No alias Importin-beta, N-terminal domain 0.08 OF
EGR52141 No alias Exportin-2, C-terminal 0.07 OF
ESU13381 No alias Exportin-2, central domain 0.08 OF
KHC83526 No alias hypothetical protein;Cse1;"CAS/CSE protein,... 0.06 OF
MGG_03994T0 No alias Importin alpha re-exporter [Source:UniProtKB/TrEMBL;Acc:G4NGY3] 0.14 OF
POW10230 No alias Importin-beta, N-terminal domain;Exportin-2, central domain 0.07 OF
SPBC30B4.05.1 No alias karyopherin Kap109 [Source:PomBase;Acc:SPBC30B4.05] 0.05 OF

Type GO Term Name Evidence Source
MF GO:0005515 protein binding IEA Interproscan
BP GO:0006886 intracellular protein transport IEA Interproscan
MF GO:0008536 Ran GTPase binding IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR001494 Importin-beta_N 24 96
IPR013713 XPO2_central 150 520
IPR005043 XPO2_C 521 955
No external refs found!