YGL124C

Description : Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy, the CVT pathway and mitophagy; potential Cdc28 substrate [Source:SGD;Acc:S000003092]

Gene families : OG_03_0001948 (OF) Phylogenetic Tree(s): OG0001948_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YGL124C
Cluster	HCCA: Cluster_23

Target	Alias	Description	ECC score	Gene Family Method
CBF86164	No alias	Vacuolar fusion protein mon1	0.02	OF
EAL87594	No alias	conserved hypothetical protein	0.02	OF
EDO00110	No alias	Vacuolar fusion protein Mon1	0.01	OF
ESU13277	No alias	Vacuolar fusion protein Mon1	0.02	OF
SPAC1D4.03c.1	No alias	autophagy associated protein Aut12 (predicted)...	0.04	OF

Type	GO Term	Name	Evidence	Source
BP	GO:0006605	protein targeting	None	Extended
BP	GO:0006623	protein targeting to vacuole	IEA	Interproscan
BP	GO:0006810	transport	None	Extended
BP	GO:0006886	intracellular protein transport	None	Extended
BP	GO:0007034	vacuolar transport	None	Extended
BP	GO:0008104	protein localization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0015031	protein transport	None	Extended
BP	GO:0015833	peptide transport	None	Extended
BP	GO:0033036	macromolecule localization	None	Extended
BP	GO:0033365	protein localization to organelle	None	Extended
BP	GO:0034613	cellular protein localization	None	Extended
BP	GO:0042886	amide transport	None	Extended
BP	GO:0045184	establishment of protein localization	None	Extended
BP	GO:0046907	intracellular transport	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0051641	cellular localization	None	Extended
BP	GO:0051649	establishment of localization in cell	None	Extended
BP	GO:0070727	cellular macromolecule localization	None	Extended
BP	GO:0071702	organic substance transport	None	Extended
BP	GO:0071705	nitrogen compound transport	None	Extended
BP	GO:0072594	establishment of protein localization to organelle	None	Extended
BP	GO:0072665	protein localization to vacuole	None	Extended
BP	GO:0072666	establishment of protein localization to vacuole	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR004353	Mon1	181	643

External Links

No external refs found!

YGL124C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation