YBL068W

Description : 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic [Source:SGD;Acc:S000000164]

Gene families : OG_03_0000298 (OF) Phylogenetic Tree(s): OG0000298_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YBL068W
Cluster	HCCA: Cluster_55

Target	Alias	Description	ECC score	Gene Family Method
AFR96555	No alias	ribose-phosphate pyrophosphokinase;Phosphoribosyl...	0.02	OF
AFR98791	No alias	ribose-phosphate pyrophosphokinase;N-terminal domain of...	0.04	OF
CAG80285	No alias	Ribose-phosphate pyrophosphokinase	0.04	OF
CAG82575	No alias	Ribose-phosphate pyrophosphokinase, N-terminal domain	0.06	OF
CAK44332	No alias	N-terminal domain of ribose phosphate pyrophosphokinase	0.02	OF
CBF83270	No alias	ribose-phosphate pyrophosphokinase	0.03	OF
EAA26722	No alias	Ribose-phosphate pyrophosphokinase, N-terminal domain	0.02	OF
EAL92246	No alias	ribose-phosphate pyrophosphokinase	0.02	OF
EDN96027	No alias	Ribose-phosphate pyrophosphokinase, N-terminal domain	0.02	OF
ESU15853	No alias	ribose-phosphate pyrophosphokinase I	0.01	OF
ESU17930	No alias	ribose-phosphate pyrophosphokinase II	0.03	OF
KHC82253	No alias	ribose-phosphate pyrophosphokinase 1;Phosphoribosyl...	0.06	OF
MGG_06678T0	No alias	Ribose-phosphate pyrophosphokinase 5...	0.01	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004749	ribose phosphate diphosphokinase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009165	nucleotide biosynthetic process	IEA	Interproscan
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016778	diphosphotransferase activity	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034654	nucleobase-containing compound biosynthetic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
BP	GO:1901293	nucleoside phosphate biosynthetic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR029099	Pribosyltran_N	14	132
IPR005946	Rib-P_diPkinase	215	321

External Links

No external refs found!

YBL068W

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation