Description : 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic [Source:SGD;Acc:S000000164]

Gene families : OG_03_0000298 (OF) Phylogenetic Tree(s): OG0000298_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YBL068W
Cluster HCCA: Cluster_55

Target Alias Description ECC score Gene Family Method Actions
AFR96555 No alias ribose-phosphate pyrophosphokinase;Phosphoribosyl... 0.02 OF
AFR98791 No alias ribose-phosphate pyrophosphokinase;N-terminal domain of... 0.04 OF
CAG80285 No alias Ribose-phosphate pyrophosphokinase 0.04 OF
CAG82575 No alias Ribose-phosphate pyrophosphokinase, N-terminal domain 0.06 OF
CAK44332 No alias N-terminal domain of ribose phosphate pyrophosphokinase 0.02 OF
CBF83270 No alias ribose-phosphate pyrophosphokinase 0.03 OF
EAA26722 No alias Ribose-phosphate pyrophosphokinase, N-terminal domain 0.02 OF
EAL92246 No alias ribose-phosphate pyrophosphokinase 0.02 OF
EDN96027 No alias Ribose-phosphate pyrophosphokinase, N-terminal domain 0.02 OF
ESU15853 No alias ribose-phosphate pyrophosphokinase I 0.01 OF
ESU17930 No alias ribose-phosphate pyrophosphokinase II 0.03 OF
KHC82253 No alias ribose-phosphate pyrophosphokinase 1;Phosphoribosyl... 0.06 OF
MGG_06678T0 No alias Ribose-phosphate pyrophosphokinase 5... 0.01 OF

Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEA Interproscan
MF GO:0004749 ribose phosphate diphosphokinase activity IEA Interproscan
BP GO:0009165 nucleotide biosynthetic process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR029099 Pribosyltran_N 14 132
IPR005946 Rib-P_diPkinase 215 321
No external refs found!