YER049W


Description : Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate [Source:SGD;Acc:S000000851]


Gene families : OG_03_0002109 (OF) Phylogenetic Tree(s): OG0002109_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: YER049W
Cluster HCCA: Cluster_69

Target Alias Description ECC score Gene Family Method Actions
POW03351 No alias Oxoglutarate/iron-dependent oxygenase, C-terminal... 0.04 OF
SPBC6B1.08c.1 No alias 2-oxoglutarate and Fe(II) dioxygenase domain containing... 0.1 OF

Type GO Term Name Evidence Source
MF GO:0005506 iron ion binding IEA Interproscan
MF GO:0016706 2-oxoglutarate-dependent dioxygenase activity IEA Interproscan
MF GO:0031418 L-ascorbic acid binding IEA Interproscan
BP GO:0055114 oxidation-reduction process IEA Interproscan
Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR019601 Oxoglutarate/Fe-dep_Oase_C 334 638
IPR039558 TPA1/OFD1_N 145 246
No external refs found!