YBL023C

Description : Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000000119]

Gene families : OG_03_0002205 (OF) Phylogenetic Tree(s): OG0002205_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YBL023C
Cluster	HCCA: Cluster_41

Target	Alias	Description	ECC score	Gene Family Method
AFR96561	No alias	minichromosome maintenance protein 2;MCM P-loop...	0.17	OF
AOA70309	No alias	DNA replication licensing factor Mcm2	0.09	OF
CAG77808	No alias	MCM N-terminal domain	0.14	OF
CAK40318	No alias	MCM N-terminal domain	0.06	OF
CBF86963	No alias	hypothetical protein similar to DNA replication licensing factor	0.11	OF
EAA31737	No alias	MCM N-terminal domain	0.12	OF
EAL92185	No alias	DNA replication licensing factor Mcm2, putative	0.14	OF
EAU91392	No alias	DNA replication licensing factor cdc19	0.07	OF
EDN91619	No alias	MCM domain	0.05	OF
EGR44530	No alias	MCM, AAA-lid domain	0.16	OF
EJF58199	No alias	MCM OB domain	0.03	OF
ESU08083	No alias	DNA replication licensing factor mcm2	0.09	OF
KHC71329	No alias	minichromosome maintenance protein 2;MCM N-terminal...	0.18	OF
MGG_08122T0	No alias	DNA replication licensing factor mcm2...	0.03	OF
POW15502	No alias	MCM OB domain;MCM N-terminal domain;MCM domain;MCM,...	0.02	OF
SPBC4.04c.1	No alias	MCM complex subunit Mcm2 [Source:PomBase;Acc:SPBC4.04c]	0.05	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006270	DNA replication initiation	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010639	negative regulation of organelle organization	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0032780	negative regulation of ATPase activity	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033043	regulation of organelle organization	None	Extended
BP	GO:0033044	regulation of chromosome organization	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
CC	GO:0042555	MCM complex	IEA	Interproscan
BP	GO:0043086	negative regulation of catalytic activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043462	regulation of ATPase activity	None	Extended
BP	GO:0044092	negative regulation of molecular function	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048523	negative regulation of cellular process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050790	regulation of catalytic activity	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051095	regulation of helicase activity	None	Extended
BP	GO:0051097	negative regulation of helicase activity	None	Extended
BP	GO:0051128	regulation of cellular component organization	None	Extended
BP	GO:0051129	negative regulation of cellular component organization	None	Extended
BP	GO:0051336	regulation of hydrolase activity	None	Extended
BP	GO:0051346	negative regulation of hydrolase activity	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065009	regulation of molecular function	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1905462	regulation of DNA duplex unwinding	None	Extended
BP	GO:1905463	negative regulation of DNA duplex unwinding	None	Extended
BP	GO:1905774	regulation of DNA helicase activity	None	Extended
BP	GO:1905775	negative regulation of DNA helicase activity	IEA	Interproscan
BP	GO:2001251	negative regulation of chromosome organization	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR008045	MCM2	53	193
IPR041562	MCM_lid	761	844
IPR027925	MCM_N	209	297
IPR033762	MCM_OB	306	432
IPR001208	MCM_dom	481	703

External Links

No external refs found!

YBL023C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation