YDR283C

Description : Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691]

Gene families : OG_03_0002262 (OF) Phylogenetic Tree(s): OG0002262_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: YDR283C
Cluster	HCCA: Cluster_12

Target	Alias	Description	ECC score	Gene Family Method
AFR98401	No alias	PEK/GCN2 protein kinase;RWD domain;Anticodon binding...	0.05	OF
AOA68716	No alias	Histidyl tRNA synthetase-related domain	0.19	OF
CAG83158	No alias	Histidyl tRNA synthetase-related domain	0.07	OF
CBF86454	No alias	eIF2 alpha kinase	0.04	OF
EAL91920	No alias	protein kinase (Gcn2), putative	0.17	OF
EAU93577	No alias	other/PEK/GCN2 protein kinase	0.03	OF
EDN91219	No alias	Class II Histidinyl-tRNA synthetase (HisRS)-like...	0.06	OF
EGR49513	No alias	Histidyl tRNA synthetase-related domain	0.08	OF
EJF61645	No alias	Histidyl-tRNA synthetase	0.02	OF
ESU11058	No alias	Histidyl tRNA synthetase-related domain	0.05	OF
KHC71817	No alias	eukaryotic translation initiation factor 2-alpha...	0.12	OF
MGG_08643T0	No alias	PEK/GCN2 protein kinase [Source:UniProtKB/TrEMBL;Acc:G4ML35]	0.05	OF
POW06187	No alias	Protein kinase domain;Protein kinase domain;Protein...	0.05	OF
SPBC36B7.09.1	No alias	eIF2 alpha kinase Gcn2 [Source:PomBase;Acc:SPBC36B7.09]	0.04	OF

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004672	protein kinase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	IEA	Interproscan
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006468	protein phosphorylation	IEA	Interproscan
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0036211	protein modification process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
No Predicted GO terms available for this sequence

InterPro domains	Description	Start	Stop
IPR024435	HisRS-related_dom	1387	1657
IPR006575	RWD-domain	13	125
IPR000719	Prot_kinase_dom	748	981
IPR000719	Prot_kinase_dom	299	526
IPR000719	Prot_kinase_dom	599	669
IPR041715	HisRS-like_core	1076	1356

External Links

No external refs found!

YDR283C

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation