Description : Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2 [Source:SGD;Acc:S000002588]

Gene families : OG_03_0001670 (OF) Phylogenetic Tree(s): OG0001670_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type Description Actions
Neighborhood HRR: YDR180W
Cluster HCCA: Cluster_21

Target Alias Description ECC score Gene Family Method Actions
EAU86150 No alias proline-rich protein Rad9 0.02 OF
EJF61054 No alias Sister chromatid cohesion C-terminus 0.02 OF
KHC76793 No alias cohesin loading factor subunit SCC2;HEAT repeat... 0.03 OF
POW11268 No alias Sister chromatid cohesion C-terminal domain;HEAT repeat... 0.05 OF
SPAC31A2.05c.1 No alias adherin, cohesin loading factor Mis4... 0.03 OF

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence

InterPro domains Description Start Stop
IPR024986 Nipped-B_C 1205 1385
IPR026003 Cohesin_HEAT 721 762
No external refs found!