Sequence Description Alias PCC hrr YKR031C Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions [Source:SGD;Acc:S000001739] 0.8795734446544512 1 YBR275C Protein that binds to the Rap1p C-terminus; acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; involved in control of DNA replication; contributes to resection of DNA double strand breaks (DSBs); deletion results in telomere elongation [Source:SGD;Acc:S000000479] 0.8239497249603357 6 YOR033C 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication [Source:SGD;Acc:S000005559] 0.8110887811667872 3 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 [Source:SGD;Acc:S000004732] 0.7988387471242369 10 YLL032C Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene [Source:SGD;Acc:S000003955] 0.7942043667298626 9 YPL167C Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p [Source:SGD;Acc:S000006088] 0.7857408626917645 6 YNL018C Putative protein of unknown function; YNL018C has a paralog, YNL034W, that arose from a segmental duplication [Source:SGD;Acc:S000004963] 0.7844729159213549 47 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000001505] 0.7831205344997112 12 YDL239C Protein required for spore wall formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; mediates assembly of the LEP complex, formation of the ring-like structure via interaction with spindle pole body components and prospore membrane maturation; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole [Source:SGD;Acc:S000002398] 0.7827957476072537 68 YDR104C Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains [Source:SGD;Acc:S000002511] 0.7821448948014553 14 YIL159W Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1 [Source:SGD;Acc:S000001421] 0.7805743849902695 12 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p [Source:SGD;Acc:S000004117] 0.7791542404445976 12 YLR045C Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p [Source:SGD;Acc:S000004035] 0.7777866194432586 18 YDL028C Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p [Source:SGD;Acc:S000002186] 0.7717743628501724 18 YDR326C Sterol-binding protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; contains two StART-like domains that bind sterols and a GRAM domain; co-localizes to puncta in the cortical ER with Sip3p; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes [Source:SGD;Acc:S000002734] 0.7704976080327923 15 YJR107W Putative lipase [Source:SGD;Acc:S000003868] 0.770105943081518 43 YNL171C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005115] 0.7636598414576449 18 YBR063C Putative protein of unknown function; YBR063C is not an essential gene [Source:SGD;Acc:S000000267] 0.7494457329870331 79 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000002525] 0.7481986551430017 20 YKL042W Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane [Source:SGD;Acc:S000001525] 0.7450500114548515 65 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 [Source:SGD;Acc:S000005072] 0.7440121423833261 75 YKR015C Putative protein of unknown function [Source:SGD;Acc:S000001723] 0.7418882987190503 62 YLR343W 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p [Source:SGD;Acc:S000004335] 0.7412614281677532 78 YOR365C Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication [Source:SGD;Acc:S000005892] 0.7376292233366651 25 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway [Source:SGD;Acc:S000000925] 0.7359666697139751 55 YBR045C Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p [Source:SGD;Acc:S000000249] 0.7337473687052031 87 YIL048W Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus [Source:SGD;Acc:S000001310] 0.7298760845263847 53 YHR184W Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis [Source:SGD;Acc:S000001227] 0.7284497738794489 84 YOL091W Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication [Source:SGD;Acc:S000005451] 0.7270808664733303 75 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000001209] 0.7241975387709128 31 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000003084] 0.7222802769317369 32 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress [Source:SGD;Acc:S000005775] 0.7181188484361719 62 YNL225C Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication [Source:SGD;Acc:S000005169] 0.7180812690098369 75 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p [Source:SGD;Acc:S000006258] 0.7157641422207055 82 YBR250W Protein of unknown function; associates with meiosis-specific protein Spo1p [Source:SGD;Acc:S000000454] 0.7117881553613993 76 YJL043W Putative protein of unknown function; YJL043W is a non-essential gene [Source:SGD;Acc:S000003579] 0.7073018655242969 56 YLR213C Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation [Source:SGD;Acc:S000004203] 0.704012116780381 99 YMR001C Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603] 0.697005964353694 39 YFR023W Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication [Source:SGD;Acc:S000001919] 0.695570355430983 97 YGL138C Putative protein of unknown function; has no significant sequence similarity to any known protein [Source:SGD;Acc:S000003106] 0.6950618252070002 83 YLL005C Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000003928] 0.6946934690004832 42 YML065W Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication [Source:SGD;Acc:S000004530] 0.6944853886901406 97 YOL015W Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000005375] 0.6940690260916526 78 YLR341W Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000004333] 0.6909922799862094 50 YDL186W Putative protein of unknown function; YDL186W is not an essential gene [Source:SGD;Acc:S000002345] 0.6882686615426196 59 YPL130W Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication [Source:SGD;Acc:S000006051] 0.6861112666083266 96 YFL040W Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport [Source:SGD;Acc:S000001854] 0.6842863257135559 98 YHR185C Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation [Source:SGD;Acc:S000001228] 0.6793952195010778 98 YDR263C Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication [Source:SGD;Acc:S000002671] 0.674981248134001 63 YDL155W B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication [Source:SGD;Acc:S000002314] 0.6741087004819482 64 YFL012W Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin [Source:SGD;Acc:S000001882] 0.6716495107817472 94 YLR227C Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane [Source:SGD;Acc:S000004217] 0.6693665433564028 67 YJR160C Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication [Source:SGD;Acc:S000003921] 0.6634162454971767 68 YDL187C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002346] 0.6577364450535821 72 YJR037W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces [Source:SGD;Acc:S000003798] 0.6561532064375942 90 YMR313C Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation [Source:SGD;Acc:S000004930] 0.6549234585702784 74 YFL041W Multicopper oxidase; integral membrane protein with similarity to Fet3p; may have a role in iron transport [Source:SGD;Acc:S000001853] 0.6542683399912107 75 YGL180W Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; essential for cell cycle progression from G2/M to G1 under nitrogen starvation [Source:SGD;Acc:S000003148] 0.6496601508345612 77 YLR260W Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication [Source:SGD;Acc:S000004250] 0.646365726929822 83 YDL007C-A Putative protein of unknown function [Source:SGD;Acc:S000113557] 0.6461839161501463 84 YCL021W-A Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the vacuole [Source:SGD;Acc:S000007549] 0.6382927726447855 88