Sequence Description Alias PCC hrr YDR278C Putative protein of unknown function; conserved among S. cerevisiae strains; YDR278C is not an essential gene [Source:SGD;Acc:S000002686] 0.6621634796024719 5 YDR445C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002853] 0.6002846949383496 2 YLR349W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C [Source:SGD;Acc:S000004341] 0.5754371398931997 22 YJL035C Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs [Source:SGD;Acc:S000003572] 0.5436144209587329 6 YER180C-A Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO [Source:SGD;Acc:S000028437] 0.5187711839014014 12 YKR012C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 [Source:SGD;Acc:S000001720] 0.48328326821981005 25 YPR168W Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006372] 0.46965873546600934 31 YNL078W Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network [Source:SGD;Acc:S000005022] 0.4410496081515435 46 YLR157W-D Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication [Source:SGD;Acc:S000028677] 0.4277303426528095 13 YLR137W Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species [Source:SGD;Acc:S000004127] 0.41698226039218267 56 YOR082C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W [Source:SGD;Acc:S000005608] 0.4034401888062956 44 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants [Source:SGD;Acc:S000003778] 0.40315585005076754 56 YDR015C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A [Source:SGD;Acc:S000002422] 0.3985271745154751 15 YDR126W Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion [Source:SGD;Acc:S000002533] 0.395959855972322 70 YLR141W Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p [Source:SGD;Acc:S000004131] 0.3895504205365414 88 YLR255C Putative protein of unknown function; conserved across S. cerevisiae strains [Source:SGD;Acc:S000004245] 0.38620847639720435 24 YDR076W Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p [Source:SGD;Acc:S000002483] 0.3855175986061191 80 YHL005C Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene [Source:SGD;Acc:S000000997] 0.38121638653536283 22 YOL114C Protein similar to the human peptidyl-tRNA hydrolase gene ICT1; associates with mitochondrial large subunit; may function in translation termination; YOL114C is not an essential gene [Source:SGD;Acc:S000005474] 0.37227726610690276 58 YPL041C Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length [Source:SGD;Acc:S000005962] 0.3492863481302554 46 YJL195C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 [Source:SGD;Acc:S000003731] 0.34774879573637096 29 YDR493W Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog [Source:SGD;Acc:S000002901] 0.33911953904684183 67 YPL114W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index [Source:SGD;Acc:S000006035] 0.33534806838485043 32 YMR222C Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000004835] 0.33473068849848053 65 YMR151W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 [Source:SGD;Acc:S000004759] 0.33315608651069 62 YGR096W Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family [Source:SGD;Acc:S000003328] 0.33034358413247755 76 YDL011C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W [Source:SGD;Acc:S000002169] 0.3218525566501615 63 YDR094W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W [Source:SGD;Acc:S000002501] 0.3148615612510381 70 YEL035C Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions [Source:SGD;Acc:S000000761] 0.3131699913412797 89 YJR129C S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A [Source:SGD;Acc:S000003890] 0.30983901518841983 43 YPR092W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006296] 0.2876317352616809 57 YGR269W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C [Source:SGD;Acc:S000003501] 0.2817927032915636 84 YPL222C-A Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028722] 0.27706846633592264 79 YDR095C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002502] 0.26642531464855074 59 YPR200C Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p [Source:SGD;Acc:S000006404] 0.25379835233004083 90 YCL068C Putative protein of unknown function [Source:SGD;Acc:S000000573] 0.25322792336820954 65 YJR158W Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose [Source:SGD;Acc:S000003919] 0.2519681199342967 68 YCR041W Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p [Source:SGD;Acc:S000000637] 0.23679566908955094 94 YPL080C Putative protein of unknown function; conserved across S. cerevisiae strains [Source:SGD;Acc:S000006001] 0.23546913511726844 83 YLR464W Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C [Source:SGD;Acc:S000004456] 0.22155826765628245 97 YEL076C-A Putative protein of unknown function [Source:SGD;Acc:S000002955] 0.22155826765628245 98