Sequence Description Alias PCC hrr YGR243W Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003475] 0.7326058202435486 3 YER121W Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy [Source:SGD;Acc:S000000923] 0.6479911281974292 5 YKR040C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W [Source:SGD;Acc:S000001748] 0.6009260666770948 3 YMR107W Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000004713] 0.5850136507418504 4 YLR327C Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication [Source:SGD;Acc:S000004319] 0.5618026959759491 5 YPL056C Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan [Source:SGD;Acc:S000005977] 0.5559327832681981 7 YNL157W Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication [Source:SGD;Acc:S000005101] 0.5425324796947405 45 YOR325W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 [Source:SGD;Acc:S000005852] 0.5325922006319711 8 YGL166W Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication [Source:SGD;Acc:S000003134] 0.5315720776320616 9 YDR203W Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAV2/YDR202C [Source:SGD;Acc:S000002611] 0.510040894618997 20 YPL060W Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p [Source:SGD;Acc:S000005981] 0.48316256237104455 22 YGR169C-A Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication [Source:SGD;Acc:S000028521] 0.45722452808453384 43 YDR482C Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p [Source:SGD;Acc:S000002890] 0.45343153466396224 52 YNL036W Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004981] 0.45269188453139914 19 YGR051C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene [Source:SGD;Acc:S000003283] 0.45048055449628643 16 YOR062C Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication [Source:SGD;Acc:S000005588] 0.41431609615896137 25 YPR145C-A Putative protein of unknown function [Source:SGD;Acc:S000113589] 0.41370102776401163 18 YBR016W Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication [Source:SGD;Acc:S000000220] 0.41105969795655106 68 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase [Source:SGD;Acc:S000007521] 0.39663606412026226 29 YOR020W-A Putative protein of unknown function; conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000028526] 0.3700234453395939 51 YDL011C Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W [Source:SGD;Acc:S000002169] 0.35472564473488 43 YOL026C Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex [Source:SGD;Acc:S000005386] 0.3539916368927817 65 YHR193C-A Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W [Source:SGD;Acc:S000028785] 0.34584344527986194 42 YMR174C Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact [Source:SGD;Acc:S000004786] 0.34377312887035133 79 YHR087W Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001129] 0.33107178041843877 64 YKL137W Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif [Source:SGD;Acc:S000001620] 0.32845684222889854 50 YHR072W-A Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA [Source:SGD;Acc:S000007455] 0.2949002393987938 92