Heatmap: Cluster_10 (HCCA)

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(Values are log2 transformed ratios of a genes expression in a sample divided by the mean expression level)

Gene
aqueous,WT
aqueous,KO_CRZ1
aqueous
aqueous,KO_CNA1
aqueous,KI_CNA1
Fungal cells,WT
Fungal cells,rim101 KO,rim101
Fungal cells,cdc50 KO
Yeast,Cuf1
Yeast,WT
WT
Yeast,YPD, 30C,matalpha
Yeast,YPG, 30C,matalpha
V8, 25C,matalpha
matalpha
C. neoformans culture,WT
Yeast
Mopane Tree
Pigeon Guano
Clinical
CSF/HIV-
exp. evolved
CSF/HIV+
bronch. wash/HIV-
rim101
Yeast,ex vivo CSF
Yeast,in vivo CSF
Fungal cells,IP3 kinase KO
Fungal cells,IP5 kinase KO
Fungal cells,IP6 kinase KO
Fungal cells,Parental strain
Cultured cells,inducing capsule,WT
Cultured cells,inducing capsule,GAT201(CNAG_01551) OE
Cultured cells,inducing capsule,sp1(CNAG_00156) KO
Cultured cells,inducing capsule,usv101(CNAG_05420) KO
Cultured cells,inducing capsule,P-CNAG_03437:GAT201(CNAG_01551)
Cultured cells,inducing capsule,P-CNAG_07442:GAT201(CNAG_01551)
YPD+sorbitol, 30C,WT KN99a
YPD+sorbitol, 30C,BCK1 KO
YPD+sorbitol, 30C,MKK2 KO
YPD+sorbitol, 30C
H99 cdc24a,Pathogen
H99 cdc24b,Pathogen
H99 cdc42 420a,Pathogen
H99 cdc42 420b,Pathogen
H99 HNa,Pathogen
H99 HNb,Pathogen
H99 ras_a,Pathogen
H99 ras_b,Pathogen
H99_a,Pathogen
H99_b,Pathogen
H99 ptp3_a,Pathogen
H99 ptp3_b,Pathogen
Pathogen
Pathogen,WT
YPD+H2O2,WT
YPD+H2O2
Homosapien,Cryptococcal meningitis,Pathogen,WT
Homosapien,Cryptococcal meningitis,Pathogen
rich media; 2% glucose,SIR2 KO
calorie-restricted media; 0.05% glucose,WT
calorie-restricted media; 0.05% glucose,SIR2 KO
rich media; 2% glucose,WT
CFO1::NEO
37C, CO2, 90 mins,WT
37C, CO2, 90 mins
Fungal cells
Fungal cells,ssn801 KO
Fungal cells,med13 KO
Fungal cells,med12 KO
Fungal cells,cdk8 KO
Fungal cells,kinase dead Cdk8
Fungal cells,control Cdk8,WT
bzp4 KO
hob1 KO
mbs1 KO
usv101 KO
rad53 KO
Fungal cells,hda1 KO
Homosapien,Pathogen
cna02310::NAT
PGPD1-ZNF2(D)-V5-NEO
dac2 KO
log. 30C
Homosapien,Pathogen,WT
cir1 KO
hapX KO
Homosapien,WT
Homosapien,bwc1
Fungal meningitis,Pathogen,matalpha
Fungal cells,pH4
Fungal cells,pH4,sre1 KO
Fungal cells,pH8
Fungal cells,pH8,sre1 KO
-0.4 -0.48 0.36 -0.16 -0.62 -0.45 -0.11 0.1 -1.16 0.7 0.12 - -7.62 - -10.27 -2.94 -0.32 -2.92 -2.02 -0.47 -1.95 -1.86 -6.27 -0.83 -2.26 -0.66 -1.74 -0.67 -1.74 -2.08 0.38 0.95 1.28 0.76 1.13 0.73 0.72 -1.16 -1.29 -3.54 -2.83 1.23 1.44 0.35 0.49 -0.66 -0.7 1.31 1.81 0.72 1.05 -0.14 0.35 - - 0.05 0.07 0.76 0.64 -0.79 -0.99 -0.07 -0.86 -1.62 1.04 0.6 1.0 0.6 0.79 -3.37 0.73 0.4 0.69 1.02 0.43 -0.28 0.75 -0.64 1.36 -1.99 -7.84 -7.27 1.35 -2.3 -0.82 -0.34 -0.15 0.16 0.74 -0.61 0.59 0.28 -0.48 -0.85
-2.72 -1.82 -2.42 -2.06 -2.44 -1.69 -2.61 -3.42 -0.26 -0.74 0.42 - - - -8.94 -0.95 -1.22 -0.9 0.44 1.3 -0.91 0.6 -1.14 1.78 - -2.71 - 0.47 0.12 0.78 1.55 -2.62 -2.79 -1.77 -2.17 -3.03 -3.49 -2.68 -2.95 -2.97 - 1.26 1.5 1.3 1.49 0.64 0.06 0.74 1.22 1.34 1.48 0.13 0.48 - - - - -2.48 -2.54 -1.29 -1.94 -0.98 -1.66 - -0.22 -0.09 -1.21 -0.88 -0.75 -1.49 -1.32 -0.91 -1.03 1.31 0.61 0.7 0.87 0.68 -0.94 1.49 - -6.93 0.2 -1.35 2.47 -1.84 -2.03 2.27 2.93 0.35 0.1 1.18 -1.48 -1.58
-0.45 0.27 -0.16 0.45 0.1 1.16 0.81 0.11 -4.56 0.89 0.64 -4.39 -4.29 -6.29 -4.86 -2.08 -0.62 -5.14 -4.97 -1.28 -1.8 -2.17 -9.62 -1.85 0.1 -2.29 -1.72 -2.37 -2.81 -2.78 0.4 0.65 0.17 1.85 -0.33 0.12 0.49 -0.07 -0.31 -0.5 0.28 1.88 1.83 1.34 1.42 -0.99 -0.86 1.34 1.82 1.56 1.51 -1.09 -0.56 -4.13 -5.07 -2.95 -0.34 0.25 -0.01 -2.4 -1.71 -2.42 -0.68 -2.16 -0.13 0.06 -0.16 -1.0 -1.01 -0.78 -1.7 -0.7 -0.13 1.54 0.91 1.45 1.21 -1.94 1.04 -1.02 -4.03 -5.62 -1.58 -2.02 -1.5 -0.73 0.18 1.04 1.94 -1.86 -1.66 -2.3 -0.51 -0.04
0.77 0.82 2.59 0.41 0.72 -0.38 -0.52 -0.75 -0.88 -0.45 -0.27 -0.07 -0.58 -0.81 -0.55 -2.56 -0.34 -0.9 -0.04 -2.02 -0.24 -1.72 -0.41 0.37 -1.17 -0.18 -2.8 -1.48 -1.78 -0.99 -2.18 1.04 0.17 -0.46 0.31 -0.33 -0.22 0.92 0.94 -0.45 -0.06 -1.16 -1.26 -0.82 -0.7 -1.42 -1.84 -2.17 -1.14 -0.46 -0.58 -0.68 -0.66 -1.61 -0.57 1.13 1.76 -0.58 -0.2 1.71 1.74 1.46 0.83 0.11 -0.74 -0.38 -0.43 0.0 -0.04 -4.03 0.19 0.17 -0.33 0.52 -0.7 -0.57 -0.57 -3.04 1.8 1.15 -1.8 -1.08 -0.61 - -0.84 0.83 0.46 0.65 0.82 -1.74 -1.7 -1.17 -0.58 -1.14
0.24 0.39 -0.07 0.3 -0.19 0.56 0.32 0.47 -0.91 0.17 0.07 -2.77 -3.07 -4.79 -2.42 -2.17 -1.14 -2.03 -1.97 -0.06 -2.8 -1.05 -2.86 0.33 -2.84 -2.1 -2.05 -0.25 -2.35 -1.67 0.01 1.07 1.48 1.43 0.46 1.08 1.56 -1.5 0.15 -1.16 0.01 0.27 0.63 0.31 0.43 -0.61 -0.18 0.05 0.58 0.41 0.27 0.35 0.43 0.35 0.7 -0.46 -1.02 0.0 0.0 -1.35 -0.95 -0.39 -1.67 -1.14 0.97 0.49 0.99 0.36 0.57 -0.72 0.73 -0.34 0.49 0.57 -2.59 -0.18 -0.16 -0.93 0.79 0.15 -0.62 -0.59 -4.6 -1.96 1.03 0.4 0.43 0.53 1.47 -0.39 0.12 -0.07 -0.52 -0.9
-0.95 -0.6 -0.94 -0.82 -0.78 -0.42 -0.87 -0.83 -1.6 0.07 0.28 -1.89 -1.38 -1.43 -0.42 -2.51 0.62 -0.81 -1.86 -0.3 -0.18 -1.27 -0.55 0.72 -0.93 0.9 0.19 -1.07 -1.66 -1.13 1.23 -1.93 -1.34 -1.17 1.25 -1.74 -1.47 1.52 2.0 1.9 1.88 -1.63 -2.22 -1.09 -0.97 -0.81 -0.62 -3.15 -2.44 -2.08 -1.66 -3.53 -2.82 0.37 1.02 -3.02 -0.91 0.82 0.4 0.56 1.16 0.71 0.7 -1.03 -1.74 -1.7 -1.48 -1.45 -1.66 -1.32 -2.57 -1.69 -1.53 1.07 1.21 1.77 2.18 -0.62 -0.24 2.56 0.66 0.15 -0.24 -0.7 -0.02 0.14 -0.21 -1.19 -0.51 -1.04 -0.26 0.55 -2.52 -2.22
-0.55 -0.67 -0.21 0.29 -0.53 1.08 0.99 0.23 0.39 0.86 -0.12 -0.21 -0.21 -0.59 0.18 -1.38 0.57 -0.96 -0.38 -0.78 -0.23 -0.79 -1.07 0.37 -3.14 1.29 0.02 -2.03 -2.77 -1.93 -2.22 -0.92 -0.38 -0.61 -1.85 -0.91 -0.87 -0.86 -0.31 -0.16 -0.41 -1.99 -2.97 -1.34 -1.65 -0.18 0.05 -2.8 -1.86 -1.3 -1.33 -3.17 -2.73 1.86 1.94 -4.01 -3.73 1.58 1.29 1.01 1.35 0.84 0.67 0.23 -1.39 -0.85 -0.93 -0.11 -0.48 -2.22 -1.25 0.13 -0.58 -0.72 -1.45 -0.27 -1.1 0.1 0.9 2.17 1.36 1.5 -2.08 0.41 0.37 -1.01 0.13 1.48 1.44 -0.35 -0.89 -1.01 -2.09 -2.94
-0.82 -0.85 -0.83 -1.15 -0.96 0.1 -0.49 0.19 -0.91 0.63 -0.34 -6.51 - - -7.97 -1.83 0.1 -3.5 -2.14 -1.19 -0.95 -2.18 -2.4 0.37 -1.34 0.13 -0.53 0.3 -0.92 -0.39 0.99 -0.34 0.41 0.38 1.29 -0.06 0.09 -0.11 -0.71 -1.64 0.99 1.65 1.31 0.95 0.93 -1.38 -1.47 0.54 1.08 0.31 0.19 -0.18 0.01 - - 2.28 1.62 -0.36 -0.32 0.66 0.54 0.43 0.08 -1.0 -0.31 -0.34 -0.37 0.01 0.36 1.36 -0.09 -0.51 -0.61 0.32 -1.53 -0.44 0.1 -0.91 -0.03 -0.15 - - -0.75 -1.65 0.63 -0.39 0.76 0.96 1.27 -0.86 -0.63 0.04 0.01 0.52
- - - - - - - - 2.55 -1.6 1.0 0.06 -0.53 -1.14 -0.0 -0.89 -1.61 -1.15 0.15 0.17 -0.48 0.2 -1.94 0.3 - 0.86 - 0.3 0.15 2.47 1.33 - - - - - - - - - - 0.25 0.41 0.17 -0.19 0.39 -0.44 -0.65 0.31 -0.09 -0.03 -0.22 -0.68 1.22 0.22 - - - - - - - - - -2.23 -0.71 -1.05 -1.88 -2.87 -4.54 -5.05 -0.91 -1.73 2.47 1.83 0.93 0.92 0.01 - 1.37 1.73 1.55 -4.09 0.75 3.15 - - 1.44 2.75 -1.06 -0.84 0.33 -3.33 -1.82
-0.38 -0.11 -0.99 -0.16 -0.65 0.1 0.29 -0.07 -0.72 -0.12 -0.01 - - - - -2.92 -0.46 -1.84 -0.72 0.26 -1.15 -0.47 -2.06 0.23 -1.7 -1.68 -4.72 -0.41 -1.29 -0.59 1.49 0.6 0.86 1.06 0.81 0.78 0.68 0.99 1.2 0.61 0.92 0.04 0.36 0.48 0.77 -1.03 -1.01 -0.12 0.45 0.34 0.46 0.26 0.63 - - 0.53 0.59 0.33 0.05 -0.27 0.73 0.11 -0.36 -0.83 0.52 0.28 0.7 0.36 0.64 -0.26 0.65 0.09 0.46 0.74 -2.15 -0.74 -0.06 -0.54 0.57 0.12 - - -1.14 -1.9 1.05 0.58 0.67 -0.26 -0.23 -0.07 0.32 0.76 -0.61 -1.0
-1.05 -1.34 1.89 -0.57 -1.15 -0.43 0.21 -0.23 -2.06 1.19 0.47 -3.16 -3.3 -4.44 -3.51 -2.91 -0.39 -5.81 -1.17 -0.18 -1.37 0.62 -8.14 -1.86 -1.71 0.99 -0.53 -1.19 -1.94 -1.97 1.74 0.06 0.2 0.33 3.63 0.51 0.43 -1.36 -1.34 -1.8 -4.13 0.65 0.32 0.19 -0.22 -1.55 -1.38 -0.09 0.15 -0.04 0.0 -0.49 -0.44 -2.51 -1.91 -2.96 -3.36 -0.13 0.28 -2.2 0.81 -2.32 -2.2 -1.44 -0.19 -0.19 0.35 0.43 0.18 -1.19 -0.0 0.31 0.37 1.41 -0.35 1.67 2.02 -1.8 -0.71 -0.47 -3.02 -2.42 -2.56 -4.47 1.19 0.34 0.15 0.58 1.44 -1.21 -0.89 -0.72 -1.75 -2.05
-0.74 -1.03 2.42 -0.08 -0.82 0.4 0.68 0.45 -2.92 1.6 0.32 - -8.67 - - -3.35 0.31 -5.44 -1.25 -0.48 -1.53 0.48 -12.0 -1.87 -1.82 2.06 0.27 -1.15 -2.43 -2.28 1.7 -0.08 -0.06 -0.03 2.96 -0.3 -0.13 -3.09 -2.31 -3.61 -1.62 0.78 0.35 0.04 0.04 -1.74 -1.7 0.1 0.34 0.14 0.21 -0.2 -0.5 - - -4.19 -5.92 1.1 1.17 -1.44 1.21 -1.51 -2.27 -1.2 -0.38 -0.34 0.01 -0.17 -0.26 -1.61 -0.45 -0.11 0.01 1.15 -0.69 1.44 1.85 -1.83 0.41 -0.22 - - -1.18 -3.26 1.39 0.68 0.34 0.09 1.02 -1.02 -1.04 -0.91 -1.94 -2.05
- 1.29 -0.52 - -0.2 0.77 - 2.5 0.65 -1.43 -0.34 1.25 1.27 0.87 -0.75 -3.27 0.3 -1.2 -1.35 - 0.95 -0.69 0.26 2.05 - 2.35 - - 0.38 - - - 0.85 - -0.56 - - - - - - - -0.21 -0.01 - 0.78 - - -0.09 0.9 -0.04 0.77 1.33 1.14 0.67 - - - - - 0.69 0.75 -0.36 - 0.11 0.19 1.67 - 0.16 -0.03 - - - -0.21 - - - -0.18 2.28 2.52 2.22 1.16 - 0.37 -0.74 - 0.56 - - -0.83 -0.64 -0.76 -0.55 0.75
-0.5 -1.82 -0.74 -0.63 -1.17 -1.51 -0.44 -1.19 -1.7 0.75 -0.07 - - - - -2.52 0.79 -2.01 -2.82 - -2.28 -3.64 -1.42 -0.97 0.24 0.56 2.1 -0.58 -2.39 -0.41 -0.1 0.4 0.06 0.44 -1.14 -0.54 -0.9 - -1.65 - 0.09 1.4 1.15 1.49 1.22 0.04 0.58 1.32 1.23 1.14 1.41 1.64 1.55 - - -0.84 0.18 -1.5 -3.1 0.02 1.18 -0.02 1.69 -1.2 -3.27 -0.92 -0.99 -1.72 -2.55 -2.47 -3.51 -1.18 -0.7 0.77 -0.48 1.83 0.96 -2.8 -0.62 2.25 - - -3.13 -1.56 0.9 1.02 0.01 1.24 1.26 -2.53 -1.87 -0.84 -1.34 -0.18
0.6 0.65 0.1 0.7 0.38 -1.3 -1.0 -1.22 -1.05 1.68 0.31 -0.29 -0.17 -0.89 -2.11 -3.11 -0.01 -0.11 -0.03 -0.39 -0.12 0.07 0.49 -0.49 -1.1 -0.45 0.14 -0.46 -0.42 -0.28 2.69 -0.33 -0.2 0.05 0.17 -0.4 -0.66 -1.65 -1.53 -1.63 -0.93 0.79 1.0 0.85 0.96 -1.24 -1.2 0.62 0.87 0.91 0.98 -0.04 0.33 -1.55 -1.47 -0.45 -1.49 -0.59 -0.39 0.04 0.55 0.06 -0.92 -1.11 0.47 -0.13 -0.05 -1.37 -1.0 0.51 -0.6 -1.35 -0.39 1.58 0.61 1.79 1.58 -1.44 -0.75 -0.51 -2.75 -2.89 -7.33 -1.59 -0.12 0.3 -0.66 -1.85 0.04 -0.66 -0.77 -0.89 -2.08 -1.69
0.67 0.77 2.27 0.92 0.48 0.33 -0.36 -0.3 0.8 0.09 0.68 - - - - -0.17 0.33 -2.31 -1.05 -1.77 0.26 -1.27 -1.03 -0.44 - -0.35 -0.05 0.42 -0.54 0.7 0.92 0.09 -0.78 -0.65 0.74 -1.31 -0.61 -1.02 - -1.35 -0.45 0.92 1.05 0.54 0.49 0.08 -0.22 0.43 0.92 0.55 0.74 -0.11 -0.02 - - -2.21 -0.08 0.93 0.48 0.04 -0.19 -0.18 -0.63 -1.34 -1.41 -0.38 -0.38 -0.49 -0.46 0.26 -1.33 0.18 -0.6 1.7 -0.12 1.2 1.58 -0.16 1.5 0.64 - - -4.41 -3.33 -0.3 -0.16 -0.27 0.9 1.25 -0.55 -1.54 -1.3 -2.66 -2.49
- - - - - - - - -2.93 -3.37 -0.1 - - - - - 0.1 -2.88 - - -5.51 - -2.75 - - -0.86 - -0.58 0.84 0.73 0.81 - - - - - - - - - - 2.11 1.94 3.33 3.39 -0.46 1.13 1.5 2.8 3.3 3.08 -1.47 0.96 - - - - - - - - - - - - - - - - - - - -1.07 2.01 1.4 1.84 1.35 - - -1.44 - - - - 2.57 - - - 1.8 - - - - -
1.0 0.95 0.41 0.77 0.51 -0.47 -0.53 0.37 -0.82 0.38 -0.2 - - - - -3.19 -0.7 -0.96 -0.8 -1.41 -1.01 -1.09 -0.73 0.32 -0.55 1.93 -1.08 -0.42 -0.74 -0.5 0.87 0.22 0.16 0.44 0.58 0.13 0.3 -0.94 -1.16 -2.1 -0.56 -0.15 0.09 0.04 -0.08 -1.56 -1.68 0.41 0.29 0.91 0.74 0.15 0.23 - - 1.93 0.53 0.2 0.09 -0.54 0.3 -0.16 -1.23 -0.67 0.51 0.36 0.78 -0.96 -0.31 0.76 0.05 -0.94 0.25 0.64 0.41 1.11 0.68 -0.81 0.58 1.26 - - -2.44 -1.94 0.59 1.43 0.19 0.08 0.64 0.2 -0.81 -0.58 -1.9 -1.57
0.53 0.68 0.42 0.54 0.44 0.15 0.85 -0.74 -1.18 0.42 -0.09 - - - - -1.64 -0.39 -0.63 -0.69 1.25 -0.39 -0.19 -2.25 0.96 -1.03 -1.99 -1.03 -1.21 -1.68 -0.84 0.89 0.05 0.66 0.55 -0.11 0.02 -0.08 -1.26 -0.99 -1.33 -2.3 1.16 1.09 0.41 0.65 -0.32 -0.28 0.35 1.06 0.62 0.66 -0.4 0.07 - - -0.47 -0.51 -0.06 -0.2 0.84 0.77 0.96 0.63 -0.56 0.19 -0.11 0.11 -1.3 -1.08 -1.69 -0.72 -1.3 -0.34 0.6 -1.59 -1.39 -0.54 -0.62 0.58 -0.18 - - -0.82 -3.42 0.43 0.82 1.02 1.02 1.44 0.28 1.06 1.25 0.29 0.63
-2.55 -1.88 -2.66 -2.13 -2.2 -1.72 -0.63 -2.8 -0.78 -0.21 1.3 - - - - -3.46 -2.28 -4.9 -1.04 -1.42 -0.95 0.35 -8.73 -1.1 -1.18 1.77 -0.73 -1.83 -1.73 -1.75 0.9 -0.84 -0.23 0.1 -0.91 -0.46 -0.88 -2.84 -2.26 -2.73 -2.39 -0.8 -0.85 -0.47 -0.28 -1.49 -1.52 -1.27 -0.49 -0.62 -0.37 -1.57 -0.93 - - -3.0 -2.3 -1.38 -1.29 -1.15 1.93 -1.03 -0.61 -2.61 -1.42 -1.65 -0.91 -0.84 -0.53 -0.57 -0.59 -1.14 -1.29 2.43 1.57 1.85 3.65 -2.34 -0.99 0.37 - - -0.53 -3.67 1.75 2.36 1.77 1.02 1.27 -2.31 1.64 2.05 0.47 0.79
-0.7 -0.91 -0.13 -0.08 -0.27 1.16 0.68 0.75 -2.88 0.11 -0.01 -1.16 -1.66 -1.42 -4.23 -0.43 -0.35 -0.03 -1.0 -1.51 -0.64 -1.01 0.37 0.38 -0.36 0.38 -0.9 0.67 0.13 -0.02 -0.1 -0.86 0.25 0.15 -0.99 -1.51 -1.01 -1.97 - -1.12 - 2.22 1.85 1.31 1.22 -0.44 -0.64 1.89 2.07 1.25 1.21 0.97 0.9 - - - - 0.9 0.65 -1.97 -2.79 -3.05 -2.52 -3.36 -1.6 -2.01 -1.1 -3.45 -2.8 -1.93 -1.16 -2.15 -0.79 0.82 0.2 0.56 0.68 0.69 1.39 0.65 - - -2.84 -0.61 1.46 -1.02 -1.0 0.83 1.12 0.25 -0.21 -1.09 -0.51 -0.68
0.16 0.01 0.85 0.7 0.09 1.39 1.35 0.65 0.02 -0.5 -0.3 -8.96 -9.41 -10.0 -9.84 -1.34 0.26 -1.54 0.59 1.08 -4.01 0.92 -2.41 0.73 0.02 -1.39 -3.25 0.56 -0.43 -0.28 -0.24 -3.4 -2.29 -1.52 -3.65 -9.44 -2.0 0.41 0.37 -0.33 -0.63 0.7 0.39 0.78 0.54 -0.74 -0.4 0.98 1.08 0.65 0.67 0.26 0.19 -6.86 -7.57 -0.6 -0.27 1.22 1.22 0.31 1.19 0.39 -0.01 0.64 -0.71 -0.97 -0.48 -1.05 -0.9 -2.01 -1.35 -1.36 -1.49 0.42 -0.68 0.13 -0.29 -0.29 2.25 0.97 -8.06 -9.56 -2.0 -1.61 0.34 0.44 -0.47 -0.19 0.32 0.37 0.8 1.5 -3.52 -4.4
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Details

Dark gray cells indicate values where the raw expression is zero (cannot be log-transformed). Blue cells indicate samples where the expression of the gene is below average and red cells indicate the gene is expressed above average in the sample. White cells are average.