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GO:0005852: eukaryotic translation initiation factor 3 complex (Cellular component)

"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]


There are 69 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_54 Saccharomyces cerevisiae 2.13 % 0.014193 0.041718
Cluster_7 Aspergillus fumigatus 0.88 % 0.00325 0.013811
Cluster_66 Aspergillus fumigatus 2.47 % 0.000415 0.001695
Cluster_96 Aspergillus nidulans 1.82 % 0.020725 0.040142
Cluster_46 Aspergillus nidulans 3.03 % 0.00023 0.00092
Cluster_26 Aspergillus niger 1.67 % 0.000722 0.008984
Cluster_84 Aspergillus niger 2.17 % 0.000425 0.001737
Cluster_76 Coprinopsis cinerea 1.34 % 0.000731 0.009931
Cluster_13 Cryptococcus neoformans 1.79 % 1e-06 7e-06
Cluster_40 Fusarium graminearum 2.31 % 0.0 0.0
Cluster_22 Neurospora crassa 1.23 % 4.4e-05 0.000432
Cluster_95 Postia placenta 33.33 % 0.001651 0.026411
Cluster_55 Puccinia striiformis 1.89 % 0.017441 0.031796
Cluster_85 Pyricularia oryzae 4.17 % 8.3e-05 0.001287
Cluster_31 Yarrowia lipolytica 2.07 % 4.4e-05 0.000236
Cluster_10 Schizosaccharomyces pombe 1.01 % 0.004351 0.013856
Cluster_70 Trichoderma reesei 3.33 % 0.000254 0.001542
Cluster_30 Trichoderma reesei 1.85 % 0.000822 0.002152
Cluster_81 Sclerotinia sclerotiorum 2.08 % 0.014087 0.047972
Sequences (69) (download table)

InterPro Domains

GO Terms

Family Terms