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GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 311 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_48 Saccharomyces cerevisiae 3.45 % 0.002478 0.04329
Cluster_128 Aspergillus niger 2.44 % 0.005476 0.034822
Cluster_25 Candida albicans 2.65 % 0.001309 0.020012
Cluster_74 Candida albicans 33.33 % 0.009825 0.047021
Cluster_83 Cryptococcus neoformans 3.7 % 0.003472 0.039233
Cluster_36 Fusarium graminearum 5.8 % 1e-06 0.000182
Cluster_41 Neurospora crassa 3.03 % 7.1e-05 0.006432
Cluster_18 Neurospora crassa 2.08 % 0.000304 0.002641
Cluster_17 Neurospora crassa 2.05 % 0.001997 0.017214
Cluster_81 Neurospora crassa 3.7 % 0.003968 0.015929
Cluster_31 Puccinia striiformis 1.28 % 0.010208 0.033258
Cluster_30 Schizosaccharomyces pombe 2.8 % 0.004807 0.038789
Cluster_79 Trichoderma reesei 3.77 % 0.004782 0.029127
Cluster_74 Sclerotinia sclerotiorum 2.24 % 0.00045 0.005072
Sequences (311) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms